B220/CD45R Antibody (RA3-6B2)

CD45R is an isoform of CD45, also known as B220. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: IF/IHC, IHC-P, Immunohistochemistry-Paraffin.

Showing Publications 1 - 8 of 8.

Publications using NB100-77420	Applications	Species
Estrada J, Zhan J, Mitchell P et al. OncoVEXmGM-CSFexpands tumor antigen-specific CD8+ T-cell response in preclinical models Journal for immunotherapy of cancer 2023-05-01 [PMID: 37164449] (Immunohistochemistry-Paraffin, Mouse)	Immunohistochemistry-Paraffin	Mouse
Zhu C, Lee JY, Woo JZ et al. An intranasal ASO therapeutic targeting SARS-CoV-2 Nature communications 2022-08-03 [PMID: 35922434] (IHC-P) Details: Dilutions: 1:10000	IHC-P
Yiu, YY;Hansen, PS;Torrez Dulgeroff, LB;Blacker, G;Myers, L;Galloway, S;Gars, E;Colace, O;Mansfield, P;Hasenkrug, KJ;Weissman, IL;Tal, MC; CD47 Blockade Leads to Chemokine-Dependent Monocyte Infiltration and Loss of B Cells from the Splenic Marginal Zone Journal of immunology (Baltimore, Md. : 1950) [PMID: 35236754] (IF/IHC, Mouse)	IF/IHC	Mouse
Ho WJ, Erbe R, Danilova L et al. Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways Genome biology 2021-05-13 [PMID: 33985562] (IF/IHC, Mouse)	IF/IHC	Mouse
Day YJ, Liou JT, Lee CM et al. Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice. Pain 2014-04-08 [PMID: 24721689] (IHC-P, Mouse)	IHC-P	Mouse
Hata H, Sakaguchi N, Yoshitomi H et al. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest. 2004-08-01 [PMID: 15314695]
Monteith CE, Chelack BJ, Davis WC et al. Identification of monoclonal antibodies for immunohistochemical staining of feline B lymphocytes in frozen and formalin-fixed paraffin-embedded tissues. Can J Vet Res. 1996-07-01 [PMID: 8809382]
Coffman RL. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol Rev. 1982-01-01 [PMID: 6984001]

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Shijun Yan	WB	Mouse	06/29/2016	View Summary Application Western Blot Sample Tested spleen Species Mouse

Array NB100-77420

• B220/CD45R Antibodies