Synaptophysin Products

Description

Synaptophysin (Syp I), also called the major synaptic vesicle protein p38, is an integral membrane glycoprotein found in the synaptic vesicles of brain, neuron and neuroendocrine cells. Synaptophysin is one of the most abundant membrane proteins, comprising approximately 7% of the total protein in small synaptic vesicles. In mature nerve terminals it forms a complex with the vesicular membrane protein synaptobrevin, which appears to modulate synaptobrevin's interaction with the plasma membrane-associated proteins syntaxin and SNAP25 to form the SNARE complex as a prerequisite for membrane fusion. Synaptophysin may also be used as a neuroendocrine tumor marker in both neuroscience and cancer research.

Bioinformatics

Entrez	20977 Mouse 24804 Rat 6855 Human
Uniprot	AAH64550 Human AAH64550.1 Human B2R7L6 Human NM_003179 Human NP_003170 Human P08247 Human Q62277 Mouse
Product By Gene ID	6855
Alternate Names	Major synaptic vesicle protein p38 MRX MRXSYP synaptophysin

Research Areas for Synaptophysin

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Membrane Vesicle Markers
Neuronal Cell Markers
Neuroscience
Neurotransmission
Phospho-Specific
Stem Cell Markers

Related Synaptophysin Blog Posts

Check out the latest blog posts on Synaptophysin.

Synaptophysin and Dementing Disorders  Synaptophysin (a presynaptic vesicle protein) is an integral membrane glycoprotein originally isolated from presynaptic vesicles of bovine neurons. Synaptophysin is found in all nerve terminals and synaptophysin measurements have been used to quantif...    Read more.

Characterizing Synaptophysin is "a Snap" Synaptophysin is an integral membrane glycoprotein found within the small synaptic vesicles in brain and endocrine cells. Studies with synaptophysin antibodies show that it is one of the most abundant small vesicle proteins, constituting approximately...    Read more.

Synaptophysin a Marker Protein in Neuroendocrine Cells Synaptophysin a Marker Protein in Neuroendocrine Cells Synaptophysin is a major integral membrane glycoprotein of neuronal synaptic vesicles present in virtually all synapses and shows a high degree of evolutionary conservation across the mammals. Syn...    Read more.

Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease  By Jamshed Arslan Pharm.D.  Alzheimer's disease (AD) is an irreversible brain disorder that destroys memory and thinking skills. The telltale signs of AD brains are extracellular deposits of amy...    Read more.

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