Home » VEGFR3/Flt-4 » VEGFR3/Flt-4 Antibodies » VEGFR3/Flt-4 Antibody (54716) [Unconjugated]
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VEGFR3/Flt-4 Antibody (54716) [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA(Cap)
Clone
54716
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB349-SP
Carrier Free
MAB349-500
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VEGFR3/Flt-4 Antibody (54716) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human VEGFR3
Tyr25-Ile776
Accession # P35916
Specificity
Detects human VEGFR3 in ELISAs. In ELISAs, shows 25% cross-reactivity with recombinant mouse (rm) VEGFR3 and no cross‑reactivity with rhVEGFR1 or rhVEGFR2.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FLT4
Purity Statement
Protein A or G purified from ascites
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Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.5-2.0 ug/mL
  • ELISA Standard (Matched Pair)
Application Notes
ELISA Detection: Human VEGF R3/Flt-4 Biotinylated Antibody (Catalog number BAM3492)
Standard: Recombinant Human VEGF R3/Flt-4 Fc Chimera (Catalog number 349-F4)
Publications
Read Publication using
MAB349 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for VEGFR3/Flt-4 Antibody (54716) [Unconjugated]

  • EC 2.7.10
  • EC 2.7.10.1
  • FLT4
  • Flt-4
  • fms-related tyrosine kinase 4
  • LMPH1A
  • PCLFLT41
  • soluble VEGFR3 variant 1
  • soluble VEGFR3 variant 2
  • soluble VEGFR3 variant 3
  • Tyrosine-protein kinase receptor FLT4
  • vascular endothelial growth factor receptor 3
  • VEGF R3
  • VEGFR3
  • VEGFR-3
  • VEGFR3Fms-like tyrosine kinase 4

Background

VEGFR2 (KDR/Flk-1), VEGFR1 (Flt-1) and VEGFR3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis.VEGFR3 cDNA encodes a 1298 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGFR3 is composed of a 751 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 482 aa residue cytoplasmic domain. Both VEGF-C and VEGF-D have been shown to bind and activate VEGF R3 (Flt-4). VEGFR3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGFR3 may be important for lymph angiogenesis.

  1. Ferra, N. and R. Davis-Smyth (1997) Endocrine Reviews 18:4.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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VEGFR3/Flt-4
Antibody (54716) [Unc ...
MAB349
VEGFR3/Flt-4 Antibody (54716) [Unconjugated]
Species: Hu
Applications: ELISA(Cap)

Publications for VEGFR3/Flt-4 Antibody (MAB349)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA Development.


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Bioinformatics

Gene Symbol FLT4
Uniprot