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VEGFR1/Flt-1 Antibody (CL0344)

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Immunohistochemistry-Paraffin: VEGFR1/Flt-1 Antibody (CL0344) [NBP2-52919] - Staining in human placenta and tonsil tissues. Corresponding FLT1 RNA-seq data are presented for the same tissues.
Orthogonal Strategies: Immunohistochemistry-Paraffin: VEGFR1/Flt-1 Antibody (CL0344) [NBP2-52919] - Staining in human placenta and tonsil tissues. Corresponding FLT1 RNA-seq data are presented for the same ...read more
Immunohistochemistry-Paraffin: VEGFR1/Flt-1 Antibody (CL0344) [NBP2-52919] - Staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.
Immunohistochemistry-Paraffin: VEGFR1/Flt-1 Antibody (CL0344) [NBP2-52919] - Staining of human kidney shows strong cytoplasmic positivity in endothelial cells.
Immunohistochemistry-Paraffin: VEGFR1/Flt-1 Antibody (CL0344) [NBP2-52919] - Staining of human small intestine shows strong cytoplasmic positivity in endothelial cells, as well as positivity in smooth muscle.
Immunohistochemistry-Paraffin: VEGFR1/Flt-1 Antibody (CL0344) [NBP2-52919] - Staining of human tonsil shows no cytoplasmic positivity in lymphoid cells as expected.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
CL0344
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

  

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VEGFR1/Flt-1 Antibody (CL0344) Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: LNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGS
Epitope
EPQITWFKNN
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FLT1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
VEGFR1/Flt-1 Recombinant Protein Antigen (NBP2-52919PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (80%), Rat (82%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for VEGFR1/Flt-1 Antibody (CL0344)

  • EC 2.7.10
  • EC 2.7.10.1
  • FLT
  • FLT1
  • Flt-1
  • Fms-like tyrosine kinase 1
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor)
  • FRT
  • Tyrosine-protein kinase FRT
  • Tyrosine-protein kinase receptor FLT
  • vascular endothelial growth factor receptor 1
  • Vascular permeability factor receptor
  • VEGF R1
  • VEGFR1
  • VEGFR-1

Background

Receptors for VEGF, VEGFB and PGF have tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors--the tyrosine kinases FLK1 and FLT1--are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol FLT1