USP14 Antibody (6D6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using H00009097-M04	Applications	Species
Hyrskyluoto A, Bruelle C, Lundh SH et al. Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1alpha. Hum Mol Genet. 2014-06-20 [PMID: 24951540]
Jacquemont, C Taniguchi, T. Proteasome Function Is Required for DNA Damage Response Fanconi Anemia Pathway Activation. Cancer Res; 67: 7395 - 7405. 2007-08-01 [PMID: 17671210]
Halbert D, Domenyuk V, Spetzler D et al. Aptamers and uses thereof United States Patent Application US 9958448 B2 2018-01-01

Array H00009097-M04

• USP14 Antibodies
• USP14 ELISA Kits
• USP14 Lysate
• USP14 Protein