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Tryptophan Hydroxylase 1/TPH-1 Antibody

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Western Blot: Tryptophan Hydroxylase 1/TPH-1 Antibody [NB300-176] - Western blot of human dorsal Raphe nucleus showing specifc immunolabeling of the ~55k tryptophan hydroxylase protein.
Western Blot: Tryptophan Hydroxylase 1/TPH-1 Antibody [NB300-176] - Western blot of human dorsal Raphe nucleus showing specifc immunolabeling of the ~55k tryptophan hydroxylase protein.

Product Details

Summary
Reactivity Hu, Mu, Rt, Rb(-), Bv, Ca, Eq, Fe, Gt, Gp, Ha, Pm, Sh, VoSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated

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Tryptophan Hydroxylase 1/TPH-1 Antibody Summary

Immunogen
Recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE. Accession # P17290
Specificity
Specific for endogenous levels of the ~55 kDa Tryptophan Hydroxylase 1/TPH-1 protein.
Predicted Species
Bovine (100%), Guinea Pig (100%), Feline (100%), Primate (100%), Equine (100%), Vole (100%), Canine (100%), Goat (100%), Hamster (100%), Sheep (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
TPH1
Purity
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:1000
  • Western Blot 1:1000
Theoretical MW
55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NB300-176 in the following applications:

  • WB
    1 publication

Reactivity Notes

Reactivity assumed based on sequence identity to a wide variety of mammalian species. Mouse reactivity reported in scientific literature (PMID: 28456683).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Antigen Affinity-purified

Alternate Names for Tryptophan Hydroxylase 1/TPH-1 Antibody

  • EC 1.14.16
  • EC 1.14.16.4
  • indoleacetic acid-5-hydroxylase
  • L-tryptophan hydroxylase
  • MGC119994
  • TPH
  • TPH-1
  • TPRH
  • TRPH
  • tryptophan 5-hydroxylase 1
  • Tryptophan 5-monooxygenase 1
  • tryptophan hydroxylase (tryptophan 5-monooxygenase)
  • Tryptophan Hydroxylase 1

Background

Tryptophan hydroxylase (TPH) is one of a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. It contains catalytic and regulatory domains, as well as a short tetramerization domain. TPH is the first catalytic step in the biosynthesis of serotonin in the CNS and melatonin in the pineal gland. TPH plays an important role in the pathology of several neuropsychiatric disorders, including depression, aggression, and schizophrenia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Tryptophan Hydroxylase 1/TPH-1 Antibody
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Applications: WB, IHC

Publications for Tryptophan Hydroxylase 1/TPH-1 Antibody (NB300-176)(2)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.


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Bioinformatics

Gene Symbol TPH1
Entrez
Uniprot