TREM1 Antibody (PY159) - Humanized

Images

 
The endocytosis ratio PY159 by hu-TREM1-HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 80% at antibody concentration of 0.3 nM.
TREM1 Antibody (PY159) - Humanized Activation was evaluated using PBMC. The max induction fold was approximately 3.16
Immobilized human TREM1 His at 2 ug/mL can bind TREM1 Antibody (PY159) - Humanized, EC50=0.00645 ug/mL.
Human TREM1 HEK293 cells were stained with TREM1 Antibody (PY159) - Humanized and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.7744nM.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, Func
Clone
PY159
Clonality
Monoclonal
Host
Human
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

TREM1 Antibody (PY159) - Humanized Summary

Description
Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
TREM1 / CD354
Isotype
IgG1
Clonality
Monoclonal
Host
Human
Gene
TREM1
Purity
Protein A purified
Endotoxin Note
< 0.001EU/ug,determined by LAL method.
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Functional

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A purified
Reconstitution Instructions
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for TREM1 Antibody (PY159) - Humanized

  • CD354 antigen
  • CD354
  • TREM1
  • TREM-1
  • TREM-1Triggering receptor expressed on monocytes 1
  • triggering receptor expressed on myeloid cells 1
  • triggering-receptor TREM1

Background

Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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TREM1: An inflammatory signal protein with a potential role in cancer
TREM1 is pro-inflammatory gene that stimulates neutrophil and monocyte-mediated inflammatory responses. This protein is highly expressed in adult liver, lung and spleen. It is also present in the lymph node, spinal cord and heart tissues. TREM-1 plays...  Read full blog post.

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Bioinformatics

Gene Symbol TREM1
Uniprot