SPRY2 Antibody (1E10)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 4 of 4.

Publications using H00010253-M01	Applications	Species
Lee CT, Chu CA, Wang YM et al. Dual role of sprouty2 as an inhibitor of RAS/ERK-driven proliferation and a promoter of cancer invasion in KRAS wild-type colorectal cancer Molecular carcinogenesis 2023-04-04 [PMID: 37014154] (Western Blot)	Western Blot
Ordonez-Moran P, Irmisch A, Barbachano A et al. SPROUTY2 is a b-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer. Oncogene. 2013-04-29 [PMID: 23624922]
Moghaddam SM, Amini A, Wei AQ et al. Initial Report on Differential Expression of Sprouty Proteins 1 and 2 in Human Epithelial Ovarian Cancer Cell Lines. J Oncol. 2012-11-29 [PMID: 23251157]
Barbachano A, Ordonez-Moran P et al. SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. Oncogene. 2010-06-14 [PMID: 20543868]

Array H00010253-M01

• SPRY2 Antibodies
• SPRY2 Lysate
• SPRY2 Proteins