Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234] - Staining of human skeletal muscle shows low expression as expected.
Immunohistochemistry: SPG3A Antibody [NBP1-90234] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234] - Staining of human cerebral cortex shows high expression.
Orthogonal Strategies: Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234] - Staining in human cerebral cortex and skeletal muscle tissues using anti-ATL1 antibody. Corresponding ATL1 RNA-seq data are ...read more
This antibody was developed against Recombinant Protein corresponding to amino acids: IPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVKKMGGEEFSRRYLQQLESE
Predicted Species
Rat (98%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ATL1
Purity
Immunogen affinity purified
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Mouse reactivity reported in scientific literature (PMID: 28726976).
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for SPG3A Antibody
AD-FSP
ATL1
atlastin GTPase 1
atlastin1
atlastin-1
Brain-specific GTP-binding protein
EC 3.6.5.-
FSP1
GBP3
GBP-3
GTP-binding protein 3
Guanine nucleotide-binding protein 3
guanylate-binding protein 3
hGBP3
Spastic paraplegia 3 protein A
spastic paraplegia 3A (autosomal dominant)
SPG3
SPG3A
SPG3AhGBP3
Background
SPG3A is encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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