SLC6A2/NET/Noradrenaline transporter Antibody

Images

 
Western Blot: SLC6A2/NET/Noradrenaline transporter Antibody [NBP3-12251] - Rat brain cortical membranes. 1:250 antibody in DiluObuffer. Apparent MW is 80 KDa.
Immunohistochemistry-Paraffin: SLC6A2/NET/Noradrenaline transporter Antibody [NBP3-12251] - Rat brain. 1:100 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 5X magnfication.
Immunohistochemistry-Paraffin: SLC6A2/NET/Noradrenaline transporter Antibody [NBP3-12251] - Rat brain. 1:100 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnfication.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

SLC6A2/NET/Noradrenaline transporter Antibody Summary

Immunogen
Synthetic peptide corresponding to N-terminal amino acids that are unique to noradrenaline transporter protein. The antibodies are raised utilizing linear, multiple antigenic peptides or cyclic peptide methodology.
Clonality
Polyclonal
Host
Rabbit
Gene
SLC6A2
Purity
Affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA 1:4000
  • Immunocytochemistry/ Immunofluorescence 1:100
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Paraffin 1:100
  • Immunoprecipitation 1:200
  • Western Blot 1:250

Packaging, Storage & Formulations

Storage
Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for SLC6A2/NET/Noradrenaline transporter Antibody

  • NAT1
  • NAT1neurotransmitter transporter
  • NET
  • NET1sodium-dependent noradrenaline transporter
  • Noradrenalin Transporter
  • Norepinephrine Transporter
  • SLC6A2
  • SLC6A5
  • solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • Solute carrier family 6 member 2
  • solute carrier family 6 member 5

Background

Norepinephrine Transporter [NET] (or noradrenaline transporter (NAT)) is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression (Klimek et al., 1997). Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (Serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD (Kim et al., 2006).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SLC6A2