Recombinant Rat GDNF Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Glial Cell Line-derived Neurotrophic Factor (GDNF) is a discovered neurotrophic factor that has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Neuronal subpopulations that have been shown to be affected by GDNF include motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons.

Native GDNF, a disulfide-linked homodimeric glycoprotein, is a novel member of the TGF-beta  superfamily. Rat GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein composed of two 134 amino acid residue subunits. The GDNF sequence contains two potential glycosylation sites and insect cell-expressed recombinant rat GDNF proteins are glycosylated. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Hamster, Porcine.

We have publications tested in 7 applications: Bioassay, Cell Culture, ELISA (Standard), ELISA Developmet, In Vivo, In vivo assay, Western Blot.

Showing Publications 1 - 10 of 46. Show All 46 Publications. Collapse Publications.

Publications using 512-GF	Applications	Species
Chen, Y;Zheng, YX;Li, YZ;Jia, Z;Yuan, Y; GDNF facilitates cognitive function recovery following neonatal surgical-induced learning and memory impairment via activation of the RET pathway and modulation of downstream effectors PKM? and Kalirin in rats Brain research bulletin 2024-09-11 [PMID: 39270804] (In vivo assay, Rat)	In vivo assay	Rat
Verstraelen, P;Van Remoortel, S;De Loose, N;Verboven, R;Garcia-Diaz Barriga, G;Christmann, A;Gries, M;Bessho, S;Li, J;Guerra, C;Tükel, Ç;Ibiza Martinez, S;Schäfer, KH;Timmermans, JP;De Vos, WH; Serum amyloid A3 fuels a feed-forward inflammatory response to the bacterial amyloid curli in the enteric nervous system Cellular and molecular gastroenterology and hepatology 2024-03-29 [PMID: 38556049] (Bioassay, Human)	Bioassay	Human
Doherty, C;Lodyga, M;Correa, J;Di Ciano-Oliveira, C;Plant, PJ;Bain, JR;Batt, J; Utilization of the Rat Tibial Nerve Transection Model to Evaluate Cellular and Molecular Mechanisms Underpinning Denervation-Mediated Muscle Injury International journal of molecular sciences 2024-02-03 [PMID: 38339124] (Bioassay, Rat)	Bioassay	Rat
Houghton, FM;Adams, SE;Ríos, AS;Masino, L;Purkiss, AG;Briggs, DC;Ledda, F;McDonald, NQ; Architecture and regulation of a GDNF-GFR?1 synaptic adhesion assembly Nature communications 2023-11-20 [PMID: 37985758] (Bioassay, Rat)	Bioassay	Rat
M Caillaud, ME Le Dréan, A De-Guilhem, C Le Berre-S, J Montnach, S Nedellec, G Loussouarn, V Paillé, M Neunlist, H Boudin A functional network of highly pure enteric neurons in a dish Frontiers in Neuroscience, 2023-01-06;16(0):1062253. 2023-01-06 [PMID: 36685225] (Bioassay, Rat)	Bioassay	Rat
G D'Este, M Stazi, S Negro, A Megighian, F Lista, O Rossetto, C Montecucco, M Rigoni, M Pirazzini Latrotoxin-Induced Neuromuscular Junction Degeneration Reveals Urocortin 2 as a Critical Contributor to Motor Axon Terminal Regeneration International Journal of Molecular Sciences, 2022-01-21;23(3):. 2022-01-21 [PMID: 35163106] (Bioassay, Rat)	Bioassay	Rat
J Zhao, P Lu, C Wan, Y Huang, M Cui, X Yang, Y Hu, Y Zheng, J Dong, M Wang, S Zhang, Z Liu, S Bian, X Wang, R Wang, S Ren, D Wang, Z Yao, G Chang, F Tang, XY Zhao Cell-fate transition and determination analysis of mouse male germ cells throughout development Nature Communications, 2021-11-25;12(1):6839. 2021-11-25 [PMID: 34824237] (Bioassay, Mouse)	Bioassay	Mouse
Y Xie, W Zhao, Z Zuo Glial cell-derived neurotrophic factor decrease may mediate learning, memory and behavior impairments in rats after neonatal surgery Brain research bulletin, 2021-10-30;0(0):. 2021-10-30 [PMID: 34728231] (In Vivo, Rat)	In Vivo	Rat
F Cardoso, RGJ Klein Wolt, C Godinho-Si, RG Domingues, H Ribeiro, JA da Silva, I Mahú, AI Domingos, H Veiga-Fern Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit Nature, 2021-08-18;0(0):. 2021-08-18 [PMID: 34408322] (Bioassay, Mouse)	Bioassay	Mouse
S Takaku, M Tsukamoto, N Niimi, H Yako, K Sango Exendin-4 Promotes Schwann Cell Survival/Migration and Myelination In Vitro International Journal of Molecular Sciences, 2021-03-15;22(6):. 2021-03-15 [PMID: 33804063] (Bioassay, Rat)	Bioassay	Rat
CM Wright, S Schneider, KM Smith-Edwa, F Mafra, AJL Leembrugge, MV Gonzalez, DR Kothakapa, JB Anderson, BA Maguire, T Gao, TA Missall, MJ Howard, JC Bornstein, BM Davis, RO Heuckeroth scRNA-sequencing reveals new enteric nervous system roles for GDNF, NRTN, and TBX3 Cellular and Molecular Gastroenterology and Hepatology, 2021-01-11;0(0):. 2021-01-11 [PMID: 33444816] (Bioassay, Mouse)	Bioassay	Mouse
LS VandenBosc, SG Wohl, MS Wilken, M Hooper, C Finkbeiner, K Cox, L Chipman, TA Reh Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in M�ller Glial regenerative potential Sci Rep, 2020-08-12;10(1):13615. 2020-08-12 [PMID: 32788677] (Bioassay, Mouse)	Bioassay	Mouse
A Javadi, S Mokhtari, SF Moraveji, FA Sayahpour, M Farzaneh, H Gourabi, F Esfandiari Short Time Exposure to Low Concentration of Zinc Oxide Nanoparticles Up-regulates Self-renewal and Spermatogenesis-Related Gene Expression Int. J. Biochem. Cell Biol., 2020-08-06;127(0):105822. 2020-08-06 [PMID: 32771442] (Bioassay, Mouse)	Bioassay	Mouse
BE Kerman, S Genoud, B Kurt Vatan, AM Denli, SG Ghosh, X Xu, GW Yeo, JB Aimone, FH Gage Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination J. Biol. Chem., 2020-07-09;0(0):. 2020-07-09 [PMID: 32647008] (Cell Culture, Rat)	Cell Culture	Rat
JE Hartung, MS Gold GCaMP as an indirect measure of electrical activity in rat trigeminal ganglion neurons Cell Calcium, 2020-05-30;89(0):102225. 2020-05-30 [PMID: 32505783] (Bioassay, Rat)	Bioassay	Rat
S Kuroda, Y Miyagawa, Y Sato, M Yamamoto, K Adachi, H Kinoh, WF Goins, JB Cohen, JC Glorioso, N Taniai, H Yoshida, T Okada Protocol Optimization for the Production of the Non-Cytotoxic J&deltaNI5 HSV Vector Deficient in Expression of Immediately Early Genes Mol Ther Methods Clin Dev, 2020-03-17;17(0):612-621. 2020-03-17 [PMID: 32300608] (Bioassay, Rat)	Bioassay	Rat
K Fu, S Tian, H Tan, C Wang, H Wang, M Wang, Y Wang, Z Chen, Y Wang, Q Yue, Q Xu, S Zhang, H Li, J Xie, M Lin, M Luo, F Chen, L Ye, K Zheng Biological and RNA regulatory function of MOV10 in mammalian germ cells BMC Biol., 2019-05-14;17(1):39. 2019-05-14 [PMID: 31088452] (Bioassay, Mouse)	Bioassay	Mouse
C Wu, ME Watts, LL Rubin MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Cell Rep, 2019-01-29;26(5):1143-1156.e5. 2019-01-29 [PMID: 30699345] (Bioassay, Mouse)	Bioassay	Mouse
Y Bai, C Zhu, M Feng, H Wei, L Li, X Tian, Z Zhao, S Liu, N Ma, X Zhang, R Shi, C Fu, Z Wu, S Zhang Previously claimed male germline stem cells from porcine testis are actually progenitor Leydig cells Stem Cell Res Ther, 2018-07-18;9(1):200. 2018-07-18 [PMID: 30021628] (Bioassay, Porcine)	Bioassay	Porcine
KL Gibbs, B Kalmar, ER Rhymes, AD Fellows, M Ahmed, P Whiting, CH Davies, L Greensmith, G Schiavo Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS Cell Death Dis, 2018-05-22;9(6):596. 2018-05-22 [PMID: 29789529] (Bioassay, Mouse)	Bioassay	Mouse
JR Cabrera, AJ Charron, DA Leib Neuronal subtype determines HSV-1 Latency-Associated-Transcript (LAT) promoter activity during latency J. Virol., 2018-06-13;0(0):. 2018-06-13 [PMID: 29643250] (Cell Culture, Mouse)	Cell Culture	Mouse
N Aoki, K Mochizuki, Y Matsui DNA methylation of the Fthl17 5'-upstream region regulates differential Fthl17 expression in lung cancer cells and germline stem cells PLoS ONE, 2017-02-16;12(2):e0172219. 2017-02-16 [PMID: 28207785] (Bioassay, Mouse)	Bioassay	Mouse
In�Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells Cell Rep, 2016-12-06;17(10):2789-2804. 2016-12-06 [PMID: 27926879] (Bioassay, Mouse)	Bioassay	Mouse
A system to study mechanisms of neuromuscular junction development and maintenance Development, 2016-05-25;0(0):. 2016-05-25 [PMID: 27226316] (Bioassay, Rat)	Bioassay	Rat
A Suzuki, M Hirasaki, T Hishida, J Wu, D Okamura, A Ueda, M Nishimoto, Y Nakachi, Y Mizuno, Y Okazaki, Y Matsui, JC Izpisua Be, A Okuda Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells Nat Commun, 2016-03-30;7(0):11056. 2016-03-30 [PMID: 27025988] (Bioassay, Mouse)	Bioassay	Mouse
Schmieg N, Thomas C, Yabe A, Lynch D, Iglesias T, Chakravarty P, Schiavo G Novel Kidins220/ARMS Splice Isoforms: Potential Specific Regulators of Neuronal and Cardiovascular Development. PLoS ONE, 2015-06-17;10(6):e0129944. 2015-06-17 [PMID: 26083449] (Bioassay, Mouse)	Bioassay	Mouse
Lim , Jung Jin, Seol , Dong Won, Choi , Kyung He, Shin , Dong Hyu, Kim , Hyung Jo, Song , Seung-Hu, Lee , Dong Ryu Spermatogonial stem cell enrichment using simple grafting of testis and in vitro cultivation. Sci Rep, 2014-08-01;4(0):5923. 2014-08-01 [PMID: 25080919] (Bioassay, Mouse)	Bioassay	Mouse
Fonseca-Pereira D, Arroz-Madeira S, Rodrigues-Campos M, Barbosa I, Domingues R, Bento T, Almeida A, Ribeiro H, Potocnik A, Enomoto H, Veiga-Fernandes H The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function. Nature, 2014-07-27;514(7520):98-101. 2014-07-27 [PMID: 25079320] (Bioassay, Mouse)	Bioassay	Mouse
Terenzio M, Golding M, Russell M, Wicher K, Rosewell I, Spencer-Dene B, Ish-Horowicz D, Schiavo G Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors. EMBO J, 2014-06-11;33(14):1582-98. 2014-06-11 [PMID: 24920579] (Bioassay, Mouse)	Bioassay	Mouse
Lim J, Shim M, Lee J, Lee D Three-step method for proliferation and differentiation of human embryonic stem cell (hESC)-derived male germ cells. PLoS ONE, 2014-04-01;9(4):e90454. 2014-04-01 [PMID: 24690677] (Bioassay, Human)	Bioassay	Human
Matsumoto , Shinji, Fujii , Shinsuke, Sato , Akira, Ibuka , Souji, Kagawa , Yoshinor, Ishii , Masaru, Kikuchi , Akira A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. EMBO J, 2014-02-20;33(7):702-18. 2014-02-20 [PMID: 24562386] (Bioassay, Mouse)	Bioassay	Mouse
Sakuraba , Juichi, Shintani , Takafumi, Tani , Sachiko, Noda , Masaharu Substrate specificity of R3 receptor-like protein-tyrosine phosphatase subfamily toward receptor protein-tyrosine kinases. J Biol Chem, 2013-06-28;288(32):23421-31. 2013-06-28 [PMID: 23814054] (Bioassay, Rat)	Bioassay	Rat
Dovere , Lisa, Fera , Stefania, Grasso , Margheri, Lamberti , Dante, Gargioli , Cesare, Muciaccia , Barbara, Lustri , Anna Mar, Stefanini , Mario, Vicini , Elena The niche-derived glial cell line-derived neurotrophic factor (GDNF) induces migration of mouse spermatogonial stem/progenitor cells. PLoS ONE, 2013-04-22;8(4):e59431. 2013-04-22 [PMID: 23613711] (Bioassay, Mouse)	Bioassay	Mouse
Hong , Weimin C, Amara , Susan G Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB J, 2013-04-23;27(8):2995-3007. 2013-04-23 [PMID: 23612789] (Bioassay, Rat)	Bioassay	Rat
Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling. Dev Biol, 2013-03-26;377(2):415-27. 2013-03-26 [PMID: 23537899] (Bioassay, Mouse)	Bioassay	Mouse
Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, Klein R Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci, 2013-03-20;33(12):5399-410. 2013-03-20 [PMID: 23516305] (Bioassay, Mouse)	Bioassay	Mouse
Euteneuer S, Yang K, Chavez E, Leichtle A, Loers G, Olshansky A, Pak K, Schachner M, Ryan A Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM). Mol Cell Neurosci, 2012-12-20;54(0):30-43. 2012-12-20 [PMID: 23262364] (Bioassay, Rat)	Bioassay	Rat
Non-viral gene therapy for GDNF production in RCS rat: the crucial role of the plasmid dose. Gene Ther., 2011-10-13;19(9):886-98. 2011-10-13 [PMID: 21993171] (ELISA (Standard), Western Blot)	ELISA (Standard), Western Blot
Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos. Development, 2010-03-01;137(5):693-704. 2010-03-01 [PMID: 20147374] (Bioassay, Mouse)	Bioassay	Mouse
Kanatsu-Shinohara M, Muneto T, Lee J, Takenaka M, Chuma S, Nakatsuji N, Horiuchi T, Shinohara T Long-term culture of male germline stem cells from hamster testes. Biol. Reprod., 2007-12-19;78(4):611-7. 2007-12-19 [PMID: 18094355] (Bioassay, Hamster)	Bioassay	Hamster
He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. Stem Cells, 2007-10-25;26(1):266-78. 2007-10-25 [PMID: 17962702] (Bioassay, Mouse)	Bioassay	Mouse
Garbayo E, Ansorena E, Lanciego JL, Aymerich MS, Blanco-Prieto MJ Purification of bioactive glycosylated recombinant glial cell line-derived neurotrophic factor. Int J Pharm, 2007-04-06;344(1):9-15. 2007-04-06 [PMID: 17499462] (Bioassay, Western Blot, Rat)	Bioassay, Western Blot	Rat
Hamra FK, Chapman KM, Nguyen D, Garbers DL Identification of neuregulin as a factor required for formation of aligned spermatogonia. J. Biol. Chem., 2006-11-10;282(1):721-30. 2006-11-10 [PMID: 17098736] (Bioassay, Rat)	Bioassay	Rat
Murata T, Tsuboi M, Hikita K, Kaneda N Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D. J. Biol. Chem., 2006-06-13;281(32):22503-16. 2006-06-13 [PMID: 16772303] (Bioassay, Mouse)	Bioassay	Mouse
Obata K, Katsura H, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, Fukuoka T, Tokunaga A, Tominaga M, Noguchi K TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J. Clin. Invest., 2005-08-18;115(9):2393-401. 2005-08-18 [PMID: 16110328] (In Vivo, Rat)	In Vivo	Rat
Carmillo P, Dago L, Day ES, Worley DS, Rossomando A, Walus L, Orozco O, Buckley C, Miller S, Tse A, Cate RL, Rosenblad C, Sah DW, Gronborg M, Whitty A Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Biochemistry, 2005-02-22;44(7):2545-54. 2005-02-22 [PMID: 15709767] (Bioassay, ELISA Developmet, Rat)	Bioassay, ELISA Developmet	Rat
Show All 46 Publications. Collapse Publications.

Array 512-GF

• GDNF Antibodies
• GDNF ELISA Kits
• GDNF Lysates
• GDNF Proteins
• GDNF ELISAs
• GDNF Proteins and Enzymes