Recombinant Porcine PD-L1/B7-H1 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Programmed cell death 1 ligand 1 (PD-L1), also known as B7-H1 and CD274, is a transmembrane glycoprotein and a member of the B7 family of immune regulatory molecules within the immunoglobulin (Ig) superfamily (1). Mature porcine PD-L1 consists of an extracellular domain (ECD) with both an Ig-V and Ig-C-like motif, a single transmembrane domain, and a short cytoplasmic tail lacking a canonical signaling motif (1). The mature ECD of porcine PD-L1 shares 74% and 67% amino acid sequence identity with human and mouse B7-H1, respectively. Alternative splicing of PD-L1 generates additional isoforms that either lack the first Ig-like domain or are truncated within the second Ig-like domain (2). B7-H1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, endothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma (3-9). B7-H1 binds to T cell B7-1/CD80 and PD-1 (7-9). It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells (6, 10). It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development (9). B7-H1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells (5, 10). In cancer, B7-H1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells (3-4, 7, 9).

Array 10397-B7

• PD-L1 Antibodies
• PD-L1 Antibody Pairs
• PD-L1 ELISA Kit
• PD-L1 Lysate
• PD-L1 Proteins
• PD-L1 Proteins and Enzymes
• PD-L1 ELISAs