Home » TREM1 » TREM1 Proteins » Recombinant Mouse TREM-1 Fc Chimera Protein, CF
Novus Biologicals products are now on bio-techne.com

Recombinant Mouse TREM-1 Fc Chimera Protein, CF

 (4 Publications)
 See All Related
Submit a Review

Images

 
There are currently no images for TREM1 (1187-TR).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

Order Details

Novus Biologicals is part of Bio-Techne

Shop this product on bio-techne.com

Novus Biologicals, part of Bio-Techne, offers 100% Guarantee

Recombinant Mouse TREM-1 Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its ability to block anti-TREM-1-induced TNF-alpha secretion by P388D1 mouse lymphoma cells. The ED50 for this effect is 2-8 ng/mL in the presence of 0.5-2 µg/mL of Goat Anti-Mouse TREM-1 (Catalog # AF1187).
Source
Mouse myeloma cell line, NS0-derived mouse TREM-1 protein
Mouse TREM-1
(Ala21-Ser202)
Accession # Q9JKE2		 SIEGRMD Human IgG1
(Pro100-Lys330)
N-terminus C-terminus
Accession #
N-terminal Sequence
Ala21
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Gene
Trem1
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
47 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
60-73 kDa, reducing conditions
Publications
Read Publications using
1187-TR in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse TREM-1 Fc Chimera Protein, CF

  • CD354 antigen
  • CD354
  • TREM1
  • TREM-1
  • TREM-1Triggering receptor expressed on monocytes 1
  • triggering receptor expressed on myeloid cells 1
  • triggering-receptor TREM1

Background

TREM-1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Ig-like domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM-1 is expressed on blood neutrophils and a subset of monocytes, and expression is up-regulated by bacterial LPS. Engagement of TREM-1 with a monoclonal antibody leads to expression of IL-8, MCP-1, and TNF-alpha suggesting that this receptor plays an important role in inflammatory responses. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with LPS-induced shock. Blockade of TREM-1 with a TREM-1/Fc fusion protein protected mice against LPS-induced shock.

  1. Bouchon, A. (2000) J. Immunol. 164:4991.
  2. Bouchon, A. (2001) Nature 410:1103.
  3. Nathan, C. and A. Ding (2001) Nature Med. 7:530.

Customers Who Viewed This Item Also Viewed...

TNF-alpha
[Unconjugated]
210-TA
SDS-PAGE TNF-alpha [Unconjugated]
Bioactivity TNF-alpha [Unconjugated]
SEC-MALS TNF-alpha [Unconjugated]
(3 Reviews)
(818 Publications)
Species: Hu
Applications: BA
IL-6 [HRP]
M6000B
N/A IL-6 [HRP]
N/A IL-6 [HRP]
N/A IL-6 [HRP]
(664 Publications)
Species: Mu
Applications: ELISA
DAP12 Antibody
NBP1-85313
Immunohistochemistry-Paraffin DAP12 Antibody
Western Blot DAP12 Antibody
Immunohistochemistry-Paraffin DAP12 Antibody
(2 Publications)
Species: Hu
Applications: IHC, IHC-P, WB
C-Reactive
Protein/CRP [Biotin]
DY1707
N/A C-Reactive Protein/CRP [Biotin]
(68 Publications)
Species: Hu
Applications: ELISA
TLR4 Antibody
(76B357.1) - BSA Free
NB100-56566
Dual RNAscope ISH-IHC TLR4 Antibody (76B357.1) - BSA Free
Immunohistochemistry TLR4 Antibody (76B357.1) - BSA Free
Immunohistochemistry TLR4 Antibody (76B357.1) - BSA Free
(5 Reviews)
(141 Publications)
Species: Bv, Hu, Ma, Mu, Po, Rt
Applications: B/N, ChIP, CyTOF-ready, DB, Dual ISH-IHC, ELISA(Cap), ELISA, Flow-CS, Flow-IC, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, In vitro, KD, KO, PAGE, WB
IL-10 [Biotin]
DY417
N/A IL-10 [Biotin]
(302 Publications)
Species: Mu
Applications: ELISA
TREM2 Antibody
[Unconjugated]
AF1729
Immunocytochemistry TREM2 Antibody [Unconjugated]
ELISA TREM2 Antibody [Unconjugated]
Knockout Validated TREM2 Antibody [Unconjugated]
(1 Review)
(57 Publications)
Species: Mu
Applications: ELISA, ICC, KO, WB
CXCL8/IL-8
Antibody (6217) [Unco ...
MAB208
Neutralization CXCL8/IL-8 Antibody (6217) [Unconjugated]
Immunocytochemistry CXCL8/IL-8 Antibody (6217) [Unconjugated]
Western Blot CXCL8/IL-8 Antibody (6217) [Unconjugated]
(1 Review)
(183 Publications)
Species: Hu
Applications: CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta), ICC, ICFlow, Neut, Simple Western, WB
Procalcitonin
Antibody (44D9)
NB120-14817
Procalcitonin Antibody (44D9)
(1 Review)
(11 Publications)
Species: Hu, Rt
Applications: ICC/IF, IHC, S-ELISA, WB
CSRP1 Antibody
AF5739
Western Blot CSRP1 Antibody
Species: Hu, Mu, Rt
Applications: WB
CCL2/JE/MCP-1 [HRP]
DCP00
N/A CCL2/JE/MCP-1 [HRP]
N/A CCL2/JE/MCP-1 [HRP]
N/A CCL2/JE/MCP-1 [HRP]
(256 Publications)
Species: Hu
Applications: ELISA
TLR2 Antibody
(TL2.1) - BSA Free
NB100-56722
Flow (Cell Surface) TLR2 Antibody (TL2.1) - BSA Free
Flow Cytometry TLR2 Antibody (TL2.1) - BSA Free
Block/ Neutralize TLR2 Antibody (TL2.1) - BSA Free
(64 Publications)
Species: Ca, Hu, Mu, Rb, Rt
Applications: B/N, DB, ELISA, Flow-CS, Flow, Func, ICC/IF, IP, In vitro, WB
NDUFA2 Antibody -
BSA Free
NBP2-93743
Immunocytochemistry/ Immunofluorescence NDUFA2 Antibody - BSA Free
Western Blot NDUFA2 Antibody - BSA Free
Species: Hu, Mu, Rt
Applications: ICC/IF, WB
CD14 [HRP]
DC140
N/A CD14 [HRP]
N/A CD14 [HRP]
(140 Publications)
Species: Hu
Applications: ELISA
ERK1 Antibody
(1E5) - BSA Free
NBP2-22203
Flow Cytometry ERK1 Antibody (1E5) - BSA Free
Immunocytochemistry/ Immunofluorescence ERK1 Antibody (1E5) - BSA Free
Immunohistochemistry-Paraffin ERK1 Antibody (1E5) - BSA Free
(1 Publication)
Species: Hu, Pm, Mu, Rt
Applications: ELISA, Flow, ICC/IF, IHC, IHC-P, WB
TREML1/TLT-1
Antibody
NBP1-84234
Immunohistochemistry-Paraffin TREML1/TLT-1 Antibody
Immunohistochemistry-Paraffin TREML1/TLT-1 Antibody
Immunohistochemistry-Paraffin TREML1/TLT-1 Antibody
Species: Hu
Applications: IHC, IHC-P, WB
IL-1 beta/IL-1F2
[Unconjugated]
201-LB
SDS-PAGE IL-1 beta/IL-1F2 [Unconjugated]
Bioactivity IL-1 beta/IL-1F2 [Unconjugated]
SEC-MALS IL-1 beta/IL-1F2 [Unconjugated]
(595 Publications)
Species: Hu
Applications: BA

Myeloperoxidase/MPO An ...
AF3667
Western Blot Myeloperoxidase/MPO Antibody [Unconjugated]
Simple Western Myeloperoxidase/MPO Antibody [Unconjugated]
Immunocytochemistry Myeloperoxidase/MPO Antibody [Unconjugated]
(3 Reviews)
(167 Publications)
Species: Hu, Mu
Applications: Dual ISH-IHC, ICC, IHC, Simple Western, WB

Publications for TREM1 (1187-TR)(4)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Bioassay, Flow Cytometry, ICC, SPR Control.


Filter By Application
Bioassay
(2)
Flow Cytometry
(1)
ICC
(1)
SPR Control
(1)
All Applications
Filter By Species
Mouse
(4)
All Species

Reviews for TREM1 (1187-TR) (0)

There are no reviews for TREM1 (1187-TR). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for TREM1 (1187-TR) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional TREM1 Products

Blogs on TREM1.

Check out the latest blog posts on TREM1.
TREM1: An inflammatory signal protein with a potential role in cancer
TREM1 is pro-inflammatory gene that stimulates neutrophil and monocyte-mediated inflammatory responses. This protein is highly expressed in adult liver, lung and spleen. It is also present in the lymph node, spinal cord and heart tissues. TREM-1 plays...  Read full blog post.
Read our latest blog and use the new citation tool on bio-techne.com

Customers Who Bought This Also Bought

1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.
TNF-alpha [Unconjugated]
210-TA-005

Contact Information

Product PDFs

  PDF SDS
  PDF Datasheet
  Request CofA

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Recombinant Mouse TREM-1 Fc Chimera Protein, CF and receive a gift card or discount.


Bioinformatics

Gene Symbol Trem1
Uniprot