Recombinant Mouse Norrin Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Norrin (also called Norrie Disease Protein or NDP) is a secreted regulatory protein that remains tightly associated with the extracellular matrix (1). At least 70 mutations of human Norrin have been identified in Norrie disease (X-linked retinal dysplasia) or in a minority of X-linked familial exudative vitreoretinopathy (FEVR). Both are disorders of retinal vascularization that cause blindness (2, 3). Norrin consists of disulfide-linked homodimers that oligomerize further via disulfide bridges to form higher order oligomers containing up to ten 12 kDa units. The cysteine-rich C-terminal domain of Norrin shows homology to von Willebrand factor, several extracellular mucin proteins, and members of the TGF-beta family. Molecular modeling studies predict that Norrin assumes the cysteine-knot structure typical of the TGF-beta family (4). Although Norrin is not related to Wnt family proteins, it functions like a Wnt protein in that it binds with high affinity to the receptor Frizzled-4, requires LDL receptor-related protein (LRP) as a co-receptor, and induces activation of the canonical Wnt signaling pathway (5). Norrin and Frizzled-4 are widely expressed, but at relatively low levels, in tissues displaying vascular phenotypes. Genetic disruption of either Norrin or Frizzled-4 results in blindness and progressive deafness due to vascular abnormalties (5-7). Female Norrin^-/- mice are infertile due to abnormalities in decidual vasculature (8). Mature mouse Norrin shares 97-98% aa identity with human, canine and bovine Norrin.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 2 of 2.

Publications using 3497-NR/CF	Applications	Species
K Strakova, P Matricon, C Yokota, E Arthofer, O Bernatik, D Rodriguez, E Arenas, J Carlsson, V Bryja, G Schulte The tyrosine Y250(2.39) in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled Cell. Signal., 2017-06-29;38(0):85-96. 2017-06-29 [PMID: 28668722] (Bioassay, Human)	Bioassay	Human
Ma M, Zhang Z, Du E, Zheng W, Gu Q, Xu X, Ke B Wnt signaling in form deprivation myopia of the mice retina. PLoS ONE, 2014-04-22;9(4):e91086. 2014-04-22 [PMID: 24755605] (In Vivo, Mouse)	In Vivo	Mouse

Array 3497-NR/CF

• Norrin/NDP Antibodies
• Norrin/NDP Lysate
• Norrin/NDP Proteins
• Norrin/NDP Proteins and Enzymes