Recombinant Mouse Jagged 1 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Jagged 1 is a 180 kDa type I transmembrane glycoprotein and member of the Delta-Serrate-Lag-2 (DSL) family of ligands that activate LIN12/Notch proteins (1). Mouse Jagged 1 is synthesized as a precursor protein that contains a 33 amino acid (aa) signal sequence, a 1034 aa extracellular region, a 26 aa transmembrane (TM) segment and a 125 aa cytoplasmic domain. The large extracellular region has a DSL (Delta, Serrate, Lag-2 consensus sequence) domain followed by 16 EGF-like repeats (2). Mouse Jagged 1 shows 98% and 99% aa identity to human and rat Jagged 1 extracellular domains respectively. The extracellular region of Jagged 1 binds to multiple Notch receptors on the cell surface as well as in solid phase binding studies. The DSL motif is necessary for binding to Notch receptors and the EGF repeats modulate the affinity of the interaction with Notch receptors (3). Notch signaling is implicated in many developmental processes in a variety of cell types. Jagged-Notch signaling specifies cell fate, regulates pattern formation, defines boundaries between different cell types, and modulates cell proliferation and differentiation. Some specific areas where Jagged is involved include hematopoiesis, myogenesis, neurogenesis and development of the vasculature (4). For instance, soluble non-transmembrane forms of Jagged1 influence behavior in fibroblast cells leading to characteristics exhibited by endothelial cells during angiogenesis (5). Soluble Jagged 1 is also capable of maintaining the survival and enhancing the expansion of human stem cells that are capable of reconstituting hematopoietic lineages in vivo (6). Furthermore, Jagged 1 is implicated in human disease: Alagille syndrome, an autosomal dominant disorder characterized by defects in liver, heart, eye, skeletal, craniofacial tissues, and kidney, is caused by mutations in Jagged 1 (7). Depending on cell types and how soluble forms of the ligand are presented, ligand binding can result in activation or inhibition of Notch signaling (8).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: In vivo assay.

Showing Publication 1 - 1 of 1.

Publication using 10969-JG	Applications	Species
Novak, S;Tanigawa, H;Singh, V;Root, SH;Schmidt, TA;Hankenson, KD;Kalajzic, I; Endothelial to mesenchymal Notch signaling regulates skeletal repair JCI insight 2024-05-23 [PMID: 38781018] (In vivo assay, Mouse)	In vivo assay	Mouse

Array 10969-JG

• Jagged 1 Antibodies
• Jagged 1 ELISA Kit
• Jagged 1 Lysate
• Jagged 1 Protein
• Jagged 1 Proteins and Enzymes
• Jagged 1 ELISAs