Recombinant Mouse IFN-beta Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon beta (IFN-beta ), also known as fibroblast IFN, is a secreted, approximately 22 kDa member of the type I interferon family of molecules (1). Mature mouse IFN-beta shares 75% and 47% amino acid sequence identity with the rat and human proteins, respectively. Fibroblasts are the major producers of IFN-beta , but it can also be produced by dendritic cells, macrophages, and endothelial cells in response to pathogens (2). It is transcriptionally regulated by TRAF3, IRF3, IRF7, and NF-kappa B (3, 4). IFN-beta -deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS) (5). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS (6-10). IFN-beta can additionally induce the expression of the anti-inflammatory cytokine IL-10 (11).

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 5 applications: Bioassay, Cell Culture, ELISA (Standard), In Vivo, In vivo assay.

Showing Publications 1 - 10 of 30. Show All 30 Publications. Collapse Publications.

Publications using 8234-MB	Applications	Species
Rajwani, J;Vishnevskiy, D;Turk, M;Naumenko, V;Gafuik, C;Kim, DS;Mah, LK;Snelling, S;Gonzales, GA;Xue, J;Chanda, A;Potts, KG;Todesco, HM;Lau, KCK;Hildebrand, KM;Chan, JA;Liao, S;Monument, MJ;Hyrcza, M;Bose, P;Jenne, CN;Canton, J;Zemp, FJ;Mahoney, DJ; VSV?M51 drives CD8+ T cell-mediated tumour regression through infection of both cancer and non-cancer cells Nature communications 2024-11-15 [PMID: 39548070] (Bioassay, Mouse)	Bioassay	Mouse
Lu, J;Hu, Z;Jiang, H;Wen, Z;Li, H;Li, J;Zeng, K;Xie, Y;Chen, H;Su, XZ;Cai, C;Yu, X; Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality Journal of advanced research 2024-08-22 [PMID: 39181199] (In vivo assay, Mouse, Transgenic Mouse)	In vivo assay	Mouse, Transgenic Mouse
Shuster, M;Lyu, Z;Augenstreich, J;Mathur, S;Ganesh, A;Ling, J;Briken, V; Salmonella Typhimurium infection inhibits macrophage IFN? signaling in a TLR4-dependent manner bioRxiv : the preprint server for biology 2024-03-05 [PMID: 38496427] (Bioassay, Mouse)	Bioassay	Mouse
Hardaker, EL;Sanseviero, E;Karmokar, A;Taylor, D;Milo, M;Michaloglou, C;Hughes, A;Mai, M;King, M;Solanki, A;Magiera, L;Miragaia, R;Kar, G;Standifer, N;Surace, M;Gill, S;Peter, A;Talbot, S;Tohumeken, S;Fryer, H;Mostafa, A;Mulgrew, K;Lam, C;Hoffmann, S;Sutton, D;Carnevalli, L;Calero-Nieto, FJ;Jones, GN;Pierce, AJ;Wilson, Z;Campbell, D;Nyoni, L;Martins, CP;Baker, T;Serrano de Almeida, G;Ramlaoui, Z;Bidar, A;Phillips, B;Boland, J;Iyer, S;Barrett, JC;Loembé, AB;Fuchs, SY;Duvvuri, U;Lou, PJ;Nance, MA;Gomez Roca, CA;Cadogan, E;Critichlow, SE;Fawell, S;Cobbold, M;Dean, E;Valge-Archer, V;Lau, A;Gabrilovich, DI;Barry, ST; The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment Nature communications 2024-02-24 [PMID: 38402224] (Bioassay, Mouse)	Bioassay	Mouse
Zhang, H;Xue, K;Li, W;Yang, X;Gou, Y;Su, X;Qian, F;Sun, L; Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity Nature communications 2024-01-04 [PMID: 38177117] (In vivo assay, Mouse, Transgenic Mouse)	In vivo assay	Mouse, Transgenic Mouse
Byun, H;Singh, GB;Xu, WK;Das, P;Reyes, A;Battenhouse, A;Wylie, DC;Lozano, MM;Dudley, JP; Apobec-Mediated Retroviral Hypermutation In Vivo is Dependent on Mouse Strain bioRxiv : the preprint server for biology 2023-11-02 [PMID: 37961113] (Bioassay, Mouse)	Bioassay	Mouse
Xia, L;Komissarova, A;Jacover, A;Shovman, Y;Arcila-Barrera, S;Tornovsky-Babeay, S;Jaya Prakashan, MM;Nasereddin, A;Plaschkes, I;Nevo, Y;Shiff, I;Yosefov-Levi, O;Izhiman, T;Medvedev, E;Eilon, E;Wilensky, A;Yona, S;Parnas, O; Systematic identification of gene combinations to target in innate immune cells to enhance T cell activation Nature communications 2023-10-09 [PMID: 37813864] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Li, Y;Xue, M;Deng, X;Dong, L;Nguyen, LXT;Ren, L;Han, L;Li, C;Xue, J;Zhao, Z;Li, W;Qing, Y;Shen, C;Tan, B;Chen, Z;Leung, K;Wang, K;Swaminathan, S;Li, L;Wunderlich, M;Mulloy, JC;Li, X;Chen, H;Zhang, B;Horne, D;Rosen, ST;Marcucci, G;Xu, M;Li, Z;Wei, M;Tian, J;Shen, B;Su, R;Chen, J; TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal Cell stem cell 2023-08-03 [PMID: 37541212]
P Dhillon, KA Mulholland, H Hu, J Park, X Sheng, A Abedini, H Liu, A Vassalotti, J Wu, K Susztak Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development Nature Communications, 2023-02-02;14(1):559. 2023-02-02 [PMID: 36732547] (Bioassay, Mouse)	Bioassay	Mouse
C Manet, Z Mansuroglu, L Conquet, V Bortolin, T Comptdaer, H Segrt, M Bourdon, R Menidjel, N Stadler, G Tian, F Herit, F Niedergang, S Souès, L Buée, MC Galas, X Montagutel, E Bonnefoy Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response Journal of Neuroinflammation, 2022-12-20;19(1):307. 2022-12-20 [PMID: 36539803] (Cell Culture, Mouse)	Cell Culture	Mouse
D Kwart, J He, S Srivatsan, C Lett, J Golubov, EM Oswald, P Poon, X Ye, J Waite, AG Zaretsky, S Haxhinasto, E Au-Yeung, NT Gupta, J Chiu, C Adler, S Cherravuru, E Malahias, N Negron, K Lanza, A Coppola, M Ni, H Song, Y Wei, GS Atwal, L Macdonald, NS Oristian, W Poueymirou, V Jankovic, M Fury, I Lowy, AJ Murphy, MA Sleeman, B Wang, D Skokos Cancer cell-derived type I interferons instruct tumor monocyte polarization Cell Reports, 2022-12-06;41(10):111769. 2022-12-06 [PMID: 36476866] (Bioassay, Mouse)	Bioassay	Mouse
N Zoellner, N Coesfeld, FH De Vos, J Denter, HC Xu, E Zimmer, B Knebel, H Al-Hasani, S Mossner, PA Lang, DM Floss, J Scheller Synthetic mimetics assigned a major role to IFNAR2 in type I interferon signaling Frontiers in Microbiology, 2022-09-02;13(0):947169. 2022-09-02 [PMID: 36118237] (Bioassay, Mouse)	Bioassay	Mouse
LC Dorman, PT Nguyen, CC Escoubas, ID Vainchtein, Y Xiao, PV Lidsky, H Nakajo, NJ Silva, C Lagares-Li, EY Wang, SE Taloma, B Cuevas, H Nakao-Inou, BM Rivera, B Schwer, C Condello, R Andino, TJ Nowakowski, AV Molofsky A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis bioRxiv : the preprint server for biology, 2023-03-20;0(0):. 2023-03-20 [PMID: 35233577] (Mouse)		Mouse
A Fedoriw, L Shi, S O'Brien, KN Smitheman, Y Wang, J Hou, C Sherk, S Rajapurkar, J Laraio, LJ Williams, C Xu, G Han, Q Feng, MT Bedford, L Wang, O Barbash, RG Kruger, P Hwu, HP Mohammad, W Peng Inhibiting Type I arginine methyltransferase activity promotes the T cell mediated antitumor immune response Cancer Immunology Research, 2022-04-01;0(0):. 2022-04-01 [PMID: 35181787] (Bioassay, Mouse)	Bioassay	Mouse
L Yang, S Chen, Q Zhao, C Pan, L Peng, Y Han, L Li, J Ruan, J Xia, H Yang, F Xu, G Cheng Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription Cell Reports, 2022-01-25;38(4):110302. 2022-01-25 [PMID: 35081346] (Bioassay, Mouse)	Bioassay	Mouse
NL Ka, GY Lim, S Hwang, SS Kim, MO Lee IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer Cell Reports, 2021-12-21;37(12):110138. 2021-12-21 [PMID: 34936865] (Bioassay, Mouse)	Bioassay	Mouse
JMJ Tan, ME Garner, JM Regeimbal, CJ Greene, JDR Márquez, DA Ammendolia, ARR McCluggage, T Li, KJ Wu, M Cemma, PP Ostrowski, B Raught, MS Diamond, S Grinstein, RM Yates, DE Higgins, JH Brumell Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes Nature Communications, 2021-08-17;12(1):4999. 2021-08-17 [PMID: 34404769] (Bioassay, Mouse)	Bioassay	Mouse
LM Sanmarco, MA Wheeler, C Gutiérrez-, CM Polonio, M Linnerbaue, FA Pinho-Ribe, Z Li, F Giovannoni, KV Batterman, G Scalisi, SEJ Zandee, ES Heck, M Alsuwailm, DL Rosene, B Becher, IM Chiu, A Prat, FJ Quintana Gut-licensed IFN&gamma+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes Nature, 2021-01-06;0(0):. 2021-01-06 [PMID: 33408417] (Bioassay, Mouse)	Bioassay	Mouse
X Guo, P Ma, Y Li, Y Yang, C Wang, T Xu, H Wang, C Li, B Mao, X Qi RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense Cell Death Differ., 2020-08-19;0(0):. 2020-08-19 [PMID: 32814877] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
D Giraldo, DR Wilcox, R Longnecker The Innate Immune Response to Herpes Simplex Virus 1 Infection Is Dampened in the Newborn Brain and Can Be Modulated by Exogenous Interferon Beta To Improve Survival MBio, 2020-05-26;11(3):. 2020-05-26 [PMID: 32457247] (In Vivo, Mouse)	In Vivo	Mouse
S Hosseini, K Michaelsen, G Grigoryan, C Chhatbar, U Kalinke, M Korte Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS Cell Rep, 2020-05-19;31(7):107666. 2020-05-19 [PMID: 32433975] (Mouse)		Mouse
Ziegler C, Allon S, Nyquist S, Mbano I, Miao V, Tzouanas C, Cao Y, Yousif A, Bals J, Hauser B, Feldman J, Muus C, Wadsworth M, Kazer S, Hughes T, Doran B, Gatter G, Vukovic M, Taliaferro F, Mead B, Guo Z, Wang J, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre J, Taylor C, Lin B, Waghray A, Mitsialis V, Dwyer D, Buchheit K, Boyce J, Barrett N, Laidlaw T, Carroll S, Colonna L, Tkachev V, Peterson C, Yu A, Zheng H, Gideon H, Winchell C, Lin P, Bingle C, Snapper S, Kropski J, Theis F, Schiller H, Zaragosi L, Barbry P, Leslie A, Kiem H, Flynn J, Fortune S, Berger B, Finberg R, Kean L, Garber M, Schmidt A, Lingwood D, Shalek A, Ordovas-Montanes J SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell, 2020-04-27;181(5):1016-1035.e19. 2020-04-27 [PMID: 32413319] (Bioassay, Mouse)	Bioassay	Mouse
N Muthalagu, T Monteverde, X Raffo-Irao, R Wiesheu, D Whyte, A Hedley, S Laing, B Kruspig, R Upstill-Go, R Shaw, S Neidler, C Rink, SA Karim, K Gyuraszova, C Nixon, W Clark, AV Biankin, LM Carlin, SB Coffelt, OJ Sansom, JP Morton, DJ Murphy Repression of the Type I Interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in Pancreatic Ductal Adenocarcinoma Cancer Discov, 2020-03-21;0(0):. 2020-03-21 [PMID: 32200350] (Bioassay, Mouse)	Bioassay	Mouse
SW Wong, BW Huang, X Hu, E Ho Kim, JP Kolb, RJ Padilla, P Xue, L Wang, TH Oguin, PA Miguez, HC Tseng, CC Ko, J Martinez Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease Cell Death Differ., 2019-05-10;0(0):. 2019-05-10 [PMID: 31076632] (Bioassay, Mouse)	Bioassay	Mouse
AM Giebel, S Hu, K Rajaram, R Finethy, E Toh, JA Brothwell, SG Morrison, RJ Suchland, BD Stein, J Coers, RP Morrison, DE Nelson Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture MBio, 2019-04-09;10(2):. 2019-04-09 [PMID: 30967464] (Bioassay, Mouse)	Bioassay	Mouse
A Singanayag, N Glanville, JL Girkin, YM Ching, A Marcellini, JD Porter, M Toussaint, RP Walton, LJ Finney, J Aniscenko, J Zhu, MB Trujillo-T, MA Calderazzo, C Grainge, SL Loo, PC Veerati, PS Pathinayak, KS Nichol, AT Reid, PL James, R Solari, PAB Wark, DA Knight, MF Moffatt, WO Cookson, MR Edwards, P Mallia, NW Bartlett, SL Johnston Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations Nat Commun, 2018-06-08;9(1):2229. 2018-06-08 [PMID: 29884817] (In Vivo, Mouse)	In Vivo	Mouse
P Mukherjee, G Hough, A Chattopadh, M Navab, HR Fogelman, D Meriwether, K Williams, S Bensinger, T Moller, KF Faull, AJ Lusis, L Iruela-Ari, KI Bostrom, P Tontonoz, ST Reddy, AM Fogelman Transgenic Tomatoes Expressing the 6F Peptide and Ezetimibe Prevent Diet-induced Increases of Interferon-? and Cholesterol 25-hydroxylase in Jejunum J. Lipid Res., 2017-06-07;0(0):. 2017-06-07 [PMID: 28592401] (ELISA (Standard))	ELISA (Standard)
A Hunger, RF Medrano, DB Zanatta, PR Del Valle, CA Merkel, TA Salles, DG Ferrari, TK Furuya, SO Bustos, R de Freitas, E Costanzi-S, BE Strauss Reestablishment of p53/Arf and interferon-? pathways mediated by a novel adenoviral vector potentiates antiviral response and immunogenic cell death Cell Death Discov, 2017-03-20;3(0):17017. 2017-03-20 [PMID: 28386458] (Bioassay, Mouse)	Bioassay	Mouse
Y Xiao, Q Zou, X Xie, T Liu, HS Li, Z Jie, J Jin, H Hu, G Manyam, L Zhang, X Cheng, H Wang, I Marie, DE Levy, SS Watowich, SC Sun The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity J. Exp. Med., 2017-03-29;0(0):. 2017-03-29 [PMID: 28356390] (Bioassay, Mouse)	Bioassay	Mouse
J C Neil Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis J. Cell. Biochem., 2017-01-10;0(0):. 2017-01-10 [PMID: 27869314] (Bioassay, Mouse)	Bioassay	Mouse
Show All 30 Publications. Collapse Publications.

Array 8234-MB

• IFN-beta Antibodies
• IFN-beta ELISA Kits
• IFN-beta Lysate
• IFN-beta Proteins
• IFN-beta Proteins and Enzymes
• IFN-beta ELISAs