Recombinant Mouse Angiopoietin-like 4 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Angiopoietin-like 4 (ANGPTL4), also known as FIAF, FARP, and PGAR, is a 55 kDa glycoprotein secreted by the liver and fat tissue. It is structurally related to the angoipoietins and contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain which can be proteolytically separated in vivo (1). Mature mouse ANGPTL4 shares 26%-30% amino acid (aa) sequence identity with mouse ANGPTL1, 2, 3, 4, 6, and 7. It shares 75% and 97% aa sequence identity with human and rat ANGPTL4, respectively. The coiled coil domain, which is not glycosylated, mediates the formation of variable sized disulfide-linked oligomers (2). This domain directly inhibits lipoprotein lipase, resulting in increased circulating triglyceride levels (3, 4). In humans, the N-terminal fragment and full length ANGPTL4 physically associate with HDL (4). In mouse, however, full length ANGPTL4 associates with HDL, while the N-terminal fragment associates with LDL (4). Circulating ANGPTL4 is decreased in type II diabetics with a subsequent loss of its normal plasma glucose lowering activity (5). Its expression in adipose tissue is induced by fasting and suppressed by feeding (6). In hypoxic areas, ANGPTL4 is induced in both vascular endothelial cells and tumor cells (7, 8). The N-terminal fragment can function as an angiogenesis inhibitor (7, 8). In contrast, the C-terminal fragment modulates cell adhesion through interactions with heparan sulfate proteoglycans, Integrins  beta 1 and beta 5, Vitronectin, and Fibronectin, thereby promoting keratinocyte migration and wound healing (7, 9, 10). ANGPTL4 additionally enhances the survival of hematopoietic and mesenchymal stem cells (11, 12). The expression of an undersialylated form of ANGPTL4 in renal podocytes contributes to proteinuria and nephrotic syndrome (13).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 5 of 5.

Publications using 4880-AN	Applications	Species
Y Son, WW Lorenz, CM Paton Linoleic acid-induced ANGPTL4 inhibits C2C12 skeletal muscle differentiation by suppressing Wnt/beta-catenin The Journal of nutritional biochemistry, 2023-03-23;0(0):109324. 2023-03-23 [PMID: 36963729] (Bioassay, Mouse)	Bioassay	Mouse
DI Cho, MJ Ahn, HH Cho, M Cho, JH Jun, BG Kang, SY Lim, SJ Yoo, MR Kim, HS Kim, SJ Lee, LT Dat, C Lee, YS Kim, Y Ahn ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation Experimental & Molecular Medicine, 2023-02-13;0(0):. 2023-02-13 [PMID: 36782020] (In Vivo, Mouse)	In Vivo	Mouse
KH Jung, MK Son, HH Yan, Z Fang, J Kim, SJ Kim, JH Park, JE Lee, YC Yoon, MS Seo, BS Han, S Ko, YJ Suh, JH Lim, DH Lee, Z Teo, JWK Wee, NS Tan, SS Hong ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a EMBO Mol Med, 2020-07-07;0(0):e11222. 2020-07-07 [PMID: 32638512] (In Vivo, Mouse)	In Vivo	Mouse
B Zhang, X Xu, X Chu, X Yu, Y Zhao Protective Effects of Angiopoietin-like 4? on the Blood-Brain Barrier in Acute Ischemic Stroke Treated with Thrombolysis in Mice Neurosci. Lett, 2017-03-04;0(0):. 2017-03-04 [PMID: 28267563] (In Vivo, Mouse)	In Vivo	Mouse
Ben-Zvi D, Barrandon O, Hadley S, Blum B, Peterson Q, Melton D Angptl4 links alpha-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism. Proc Natl Acad Sci U S A, 2015-11-30;112(50):15498-503. 2015-11-30 [PMID: 26621734] (Mouse)		Mouse

Array 4880-AN

• Angiopoietin-like Protein 4/ANGPTL4 Antibodies
• Angiopoietin-like Protein 4/ANGPTL4 ELISA Kits
• Angiopoietin-like Protein 4/ANGPTL4 Lysate
• Angiopoietin-like Protein 4/ANGPTL4 Proteins and Enzymes
• Angiopoietin-like Protein 4/ANGPTL4 ELISAs