Recombinant Human Vitamin D BP His-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Vitamin D BP (Vitamin D binding protein), also known as group-specific component and GC-globulin, is a 58 kDa, monomeric glycoprotein member of the ALB/AFP/VDB family. It was initially discovered as a major liver-derived polymorphic protein and was called group-specific component or GC in 1959 (1). Mature human Vitamin D BP is 458 amino acids (aa) in length. It contains three albumin-type domains that are accompanied by 14 intramolecular disulfide bonds (2). Mature human Vitamin D BP  is 77% aa identical to mouse Vitamin D BP. Vitamin D BP is able to bind to various forms of Vitamin D including vitamin D2, the 25‑hydroxylated forms and the active hormonal product, 1,25-dihydroxyvitamin D (Calcitriol). The major proportion of Vitamin D in blood is bound to Vitamin D BP, which transports vitamin D metabolites between skin, liver and kidney and then on to various target tissues (3). Vitamin D BP is implemented as a cause for multiple sclerosis (4). There is a strong suggestion that vitamin D and Vitamin D BP  gene polymorphism are involved in occurrence of type 2 diabetes mellitus (5). Vitamin D BP  has been associated with inflammatory process, stimulation of chemotaxis by phagocytic neutrophils and the activation and stimulation of phagocytic function by macrophages (6, 7).

Array 3778-DB

• Vitamin D BP Antibodies
• Vitamin D BP ELISA Kits
• Vitamin D BP Lysate
• Vitamin D BP Proteins
• Vitamin D BP Proteins and Enzyme
• Vitamin D BP ELISAs