Recombinant Human Serpin B2/PAI-2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Serpin B2, also known as PAI-2, is an approximately 60 kDa serine protease inhibitor (1). It is primarily secreted by macrophages and monocytes (2, 3) and can form disulfide-linked multimers (4, 5). Serpin B2 inhibits both the urokinase-type and tissue-type plasminogen activators (uPA and tPA) (3, 4, 6). Serpin B2 also promotes the clearance of uPA by enhancing its binding and uptake by LRP (7). It limits fibril formation by Huntington protein (HTT) and beta-Amyloid peptides (8). It promotes Th2 biased immune responses and is important for intestinal CCL2 production, monocyte recruitment, and nematode clearance (2, 9). A non-glycosylated form of Serpin B2 is retained intracellularly where it interferes with TNF-a induced apoptosis by protecting the Retinoblastoma protein (RB1) from calpain digestion (10). It also inhibits proteasome activity in activated endothelial cells (11). Serpin B2 is upregulated in HIV-1 infected PBMC, induces RB1 upregulation, and promotes HIV-1 replication (12). Human Serpin B2 shares 76% and 73% amino acid sequence identity with mouse and rat Serpin B2, respectively.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Bioassay.

Showing Publication 1 - 1 of 1.

Publication using 9206-PI	Applications	Species
Z Wang, M Cui, AM Shah, W Tan, N Liu, R Bassel-Dub, EN Olson Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution Cell Reports, 2020-12-08;33(10):108472. 2020-12-08 [PMID: 33296652] (Bioassay, Human)	Bioassay	Human

Array 9206-PI

• SerpinB2 Antibodies
• SerpinB2 ELISA Kits
• SerpinB2 Lysates
• SerpinB2 Proteins
• SerpinB2 Proteins and Enzyme
• SerpinB2 ELISA