Recombinant Human Resistin Protein, CF

The purchase of this product conveys to the buyer the limited, non-exclusive, non-transferable right (without the right to resell, repackage, or further sublicense) to use these reagents for non-commercial research purposes only. No other license is granted to the buyer whether expressly, by implication, by estoppel or otherwise. In particular, the purchase of this product does not include nor carry any right or license to use, develop, or otherwise exploit this product commercially, which includes without limitation, provision of services to a third party, generation of commercial databases, clinical diagnostics or therapeutics, or drug development.

This product is manufactured under a license to U.S. Patent number 7,470,522. Any party desiring rights under this patent should contact Ryogen LLC, Montebello Park, 75 Montebello Road, Suffern, NY 10901.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Resistin (resistance-to-insulin), also known as adipocyte-specific secretory factor (ADSF) and found in inflammatory zone 3 (FIZZ3), is a 10 kDa member of a small family of secreted cysteine-rich peptide hormones. These molecules purportedly play some role in inflammation, glucose metabolism, and angiogenesis (1, 2, 3, 4). Human Resistin precursor is 108 amino acids (aa) in length. It contains an 18 aa signal sequence plus a 90 aa mature region. The mature region shows an N-terminal alpha -helical tail (aa 23 ‑ 44) and a C-terminal beta ‑sheet globular head (aa 47 ‑ 108) (5 ‑ 7). The Resistin molecule circulates as either a noncovalent trimer (minor form), or a disulfide-linked homohexamer (major form). Noncovalent trimers are generated when the alpha -helical segments self-associate to form a three-stranded coiled-coil structure. Covalent hexamers subsequently appear when the free Cys at position # 26 is engaged by adjacent trimers. It is hypothesized that the hexamer is the inactive form of the molecule, and bioactivity is achieved at the target site by disulfide bond reduction (5). Although Resistin family molecules can noncovalently interact to form heterotrimers in vitro, there is no evidence to suggest this occurs in vivo with Resistin (8, 9). Mature human Resistin shares 56% and 54% aa identity with mouse and rat Resistin, respectively. Rat Resistin possesses an alternate start site at Met48; this Met is not found in the mouse molecule, however (10). Rodent Resistin is expressed by white adipocytes, splenocytes, astrocytes, and anterior pituitary epithelium (6, 11, 12). Although the function of Resistin is unclear, it would seem to block insulin-stimulated uptake of glucose by adipocytes and promote glucose release by hepatocytes (6, 13, 14). As such, it has been proposed to participate in diet‑induced insulin-sensitivity. Diets high in fat promote an increase in overall adipocyte size. Hypertrophic adipocytes are known to secrete TNF-alpha which acts locally to block ACRP30 production. Since ACRP30 is an insulin-sensitizer, a drop in ACRP30 availability leads to insulin-insensitivity, which drives increased insulin production (a compensatory mechanism). High insulin induces Resistin secretion which now antagonizes insulin action, prompting more insulin production and more Resistin secretion (15).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioassay, ELISA (Standard).

Showing Publications 1 - 4 of 4.

Publications using 1359-RN	Applications	Species
SS Chen, CH Tang, MJ Chie, CH Tsai, YC Fong, YC Lu, WC Chen, CT Lai, CY Wei, HC Tai, WY Chou, SW Wang Resistin facilitates VEGF-A-dependent angiogenesis by inhibiting miR-16-5p in human chondrosarcoma cells Cell Death Dis, 2019-01-10;10(1):31. 2019-01-10 [PMID: 30631040] (Bioassay, Human)	Bioassay	Human
Resistin reinforces interferon ?-3 to eliminate hepatitis C virus with fine-tuning from RETN single-nucleotide polymorphisms Sci Rep, 2016-08-01;6(0):30799. 2016-08-01 [PMID: 27477870] (Bioassay, Human)	Bioassay	Human
Yang C, Chang S, Chao J, Lai Y, Chang W, Hsu W, Kuo W Activation of AMP-activated protein kinase attenuates hepatocellular carcinoma cell adhesion stimulated by adipokine resistin. BMC Cancer, 2014-02-20;14(0):112. 2014-02-20 [PMID: 24555415] (Bioassay, Human)	Bioassay	Human
Umehara A, Nishioka M, Obata T A novel ultra-sensitive enzyme immunoassay for soluble human insulin receptor ectodomain and its measurement in urine from healthy subjects and patients with diabetes mellitus. Clin. Biochem., 2009-06-25;42(13):1468-75. 2009-06-25 [PMID: 19560451] (ELISA (Standard))	ELISA (Standard)

Array 1359-RN

• Resistin Antibodies
• Resistin ELISA Kits
• Resistin Lysate
• Resistin Protein
• Resistin Proteins and Enzymes
• Resistin ELISAs