Recombinant Human Fc gamma RIIA/CD32a (H167) Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Receptors for the Fc region of IgG (Fc gamma R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc gamma Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized (1-3). The activating-type receptor either has or associates non-covalently with an accessory subunit (FcR gamma or zeta chain) that has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. In contrast, the inhibitory receptor (Fc gamma RIIB) has a built-in immunoreceptor tyrosine-based inhibitory motif (ITIM) in its own cytoplasmic domain. Fc gamma RI is a high-affinity receptor that binds monomeric IgG, and Fc gamma RII and RIII are low-affinity receptors that bind aggregated or immune complexed IgG (IC). The extracellular domain of human Fc gamma RIIA shares approximately 90% amino acid sequence homology with human Fc gamma RIIB and Fc gamma RIIC. Fc gamma RIIA is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells) where inhibitory ITIM-bearing receptors may also be co-expressed and co-engaged by specific ligands. Signaling through Fc gamma RIIA results in the initiation of inflammatory responses (cytolysis, phagocytosis, degranulation and cytokine production) that can be modulated by signals from the inhibitory receptors. The strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors. Besides IC, Fc gamma RII A also binds C-reactive protein (CRP) (4, 5). Two allelic variants (R167 and H167) of Fc gamma RIIA that differ in their ability to ligate human IgG2 or CRP exist. The H167 allele has been found to have a protective effect against lupus nephritis.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioassay, ELISA Capture.

Showing Publications 1 - 2 of 2.

Publications using 9595-CD	Applications	Species
JA Torchia, AH Tavares, LS Carstensen, DY Chen, J Huang, T Xiao, S Mukherjee, PM Reeves, H Tu, AE Sluder, B Chen, DN Kotton, RA Bowen, M Saeed, MC Poznansky, GJ Freeman Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo Science Advances, 2022-12-07;8(49):eabq6527. 2022-12-07 [PMID: 36475798] (ELISA Capture, Human)	ELISA Capture	Human
TA Bates, P Lu, YJ Kang, D Schoen, M Thornton, SK McBride, C Park, D Kim, WB Messer, ME Curlin, FG Tafesse, LL Lu BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age Cell Reports, 2022-10-05;41(4):111544. 2022-10-05 [PMID: 36252569] (Bioassay, Human)	Bioassay	Human

Array 9595-CD

• Fc gamma RIIA/CD32a Antibodies
• Fc gamma RIIA/CD32a Antibody Pair
• Fc gamma RIIA/CD32a Lysate
• Fc gamma RIIA/CD32a Protein
• Fc gamma RIIA/CD32a Proteins and Enzymes