Name: Recombinant Human Complement Component C5a Protein
Brand: Novus Biologicals
SKU: 2037-C5
Price: 365 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Bioactivity

Details of Functionality	Measured by its ability to induce N-acetyl-beta -D-glucosaminidase release from differentiated U937 human histiocytic lymphoma cells. Gerard, NP and Gerard, C. (1990) Biochemistry 29:9274. The ED₅₀ for this effect is 1.5-5 ng/mL.
Source	E. coli-derived human Complement Component C5a protein Thr678-Arg751
Accession #	P01031
N-terminal Sequence	Thr678
Protein/Peptide Type	Recombinant Proteins
Gene	C5
Purity	>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note	<0.10 EU per 1 μg of the protein by the LAL method.

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity	>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions	Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Publications using 2037-C5	Applications	Species
Cristiano, C;Giorgio, C;Cocchiaro, P;Boccella, S;Cesta, MC;Castelli, V;Liguori, FM;Cuozzo, MR;Brandolini, L;Russo, R;Allegretti, M; Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy Cytokine 2023-09-16 [PMID: 37722320] (Bioassay, Human)	Bioassay	Human
Fischer, V;Bülow, JM;Krüger, BT;Ragipoglu, D;Vikman, A;Haffner-Luntzer, M;Katsoulis-Dimitriou, K;Dudeck, A;Ignatius, A; Role of Mast-Cell-Derived RANKL in Ovariectomy-Induced Bone Loss in Mice International journal of molecular sciences 2023-05-23 [PMID: 37298085] (Bioassay, Human)	Bioassay	Human
Nelke, C;Schroeter, CB;Stascheit, F;Huntemann, N;Pawlitzki, M;Willison, AG;R�uber, S;Melzer, N;Distler, U;Tenzer, S;St�hler, K;Roos, A;Meisel, A;Meuth, SG;Ruck, T; Eculizumab treatment alters the proteometabolome beyond the inhibiton of complement JCI insight 2023-05-25 [PMID: 37227781] (Bioassay, Human)	Bioassay	Human
AJ Plant-Hate, B Eryilmaz, CAW David, DE Brain, BJ Heaton, Y Perrie, NJ Liptrott Exposure of the Basophilic Cell Line KU812 to Liposomes Reveals Activation Profiles Associated with Potential Anaphylactic Responses Linked to Physico-Chemical Characteristics Pharmaceutics, 2022-11-15;14(11):. 2022-11-15 [PMID: 36432660] (Bioassay, Human)	Bioassay	Human
J Liu, X Wei, J Hu, X Tan, X Kang, L Gao, N Li, X Shi, M Yuan, W Hu, M Liu Different concentrations of C5a affect human dental pulp mesenchymal stem cells differentiation BMC Oral Health, 2021-09-24;21(1):470. 2021-09-24 [PMID: 34560867] (Bioassay, Human)	Bioassay	Human
D Medica, R Franzin, A Stasi, G Castellano, M Migliori, V Panichi, F Figliolini, L Gesualdo, G Camussi, V Cantaluppi Extracellular Vesicles Derived from Endothelial Progenitor Cells Protect Human Glomerular Endothelial Cells and Podocytes from Complement- and Cytokine-Mediated Injury Cells, 2021-07-02;10(7):. 2021-07-02 [PMID: 34359843] (Bioassay, Human)	Bioassay	Human
S Silawal, B Kohl, J Shi, G Schulze-Ta Complement Regulation in Human Tenocytes under the Influence of Anaphylatoxin C5a International Journal of Molecular Sciences, 2021-03-18;22(6):. 2021-03-18 [PMID: 33803624] (Bioassay, Human)	Bioassay	Human
N Kashiwagi, F Saito, H Maegawa, K Kaneda Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - In vitro and in vivo results Cytokine, 2021-01-01;139(0):155410. 2021-01-01 [PMID: 33395614] (Bioassay, Human)	Bioassay	Human
GI Giraldo-Ca, A Calle-Tobó, P Rozo-López, TM Colpitts, Y Park, GL Rua-Uribe, B Londono-Re Transcriptome of the Aedes aegypti Mosquito in Response to Human Complement Proteins Int J Mol Sci, 2020-09-09;21(18):. 2020-09-09 [PMID: 32916828] (Bioassay, Mosquito)	Bioassay	Mosquito
L Hong, Y Tang, S Pan, M Xu, Y Shi, S Gao, C Sui, C He, K Zheng, R Tang, Z Shi, Q Wang, H Wang Interleukin 3-induced GITR promotes the activation of human basophils Cytokine, 2020-09-02;136(0):155268. 2020-09-02 [PMID: 32889153] (Bioassay, Human)	Bioassay	Human
S Ohlsson, L Holm, C Hansson, SM Ohlsson, L Gunnarsson, Å Pettersson, L Skattum Neutrophils from ANCA-associated vasculitis patients show an increased capacity to activate the complement system via the alternative pathway after ANCA stimulation PLoS ONE, 2019-06-19;14(6):e0218272. 2019-06-19 [PMID: 31216309] (Bioassay, Cell Culture, Human)	Bioassay, Cell Culture	Human
J Paupert, E Espinosa, N Cenac, V Robert, P Laharrague, SM Evrard, L Casteilla, A Lorsignol, B Cousin Rapid and Efficient Production of Human Functional Mast Cells Through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular Cells J. Immunol., 2018-11-16;0(0):. 2018-11-16 [PMID: 30446570] (Cell Culture, Human)	Cell Culture	Human
Y Zhang, Y Cao, L Zhang, C Feng, G Zhou, G Wen Apigenin inhibits C5a-induced proliferation of human nasopharyngeal carcinoma cells through down-regulation of C5aR Biosci. Rep., 2018-05-15;0(0):. 2018-05-15 [PMID: 29685955] (Bioassay, Human)	Bioassay	Human
MC Gruda, KG Ruggeberg, P O'Sullivan, T Guliashvil, AR Scheirer, TD Golobish, VJ Capponi, PP Chan Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorbï¿½ sorbent porous polymer beads PLoS ONE, 2018-01-25;13(1):e0191676. 2018-01-25 [PMID: 29370247] (Bioassay, Human)	Bioassay	Human
Benjamin Malard Adsorption as a Contributor for Inflammatory Mediators Removal by Different Hemofiltration Membranes: A Pilot Study Artif Organs, 2016-12-02;0(0):. 2016-12-02 [PMID: 27911005] (Hemofiltration Procedure, Human)	Hemofiltration Procedure	Human
EJ Lim, Y Suh, KC Yoo, JH Lee, IG Kim, MJ Kim, JH Chang, SG Kang, SJ Lee Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells Oncotarget, 2017-01-03;8(1):1438-1448. 2017-01-03 [PMID: 27903965] (Bioassay, Human)	Bioassay	Human
Nerve Growth Factor Secretion From Pulp Fibroblasts is Modulated by Complement C5a Receptor and Implied in Neurite Outgrowth Sci Rep, 2016-08-19;6(0):31799. 2016-08-19 [PMID: 27539194] (Bioassay, Human)	Bioassay	Human
Yatime , Laure, Maasch , Christia, Hoehlig , Kai, Klussmann , Sven, Andersen , Gregers, Vater , Axel Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer. Nat Commun, 2015-04-22;6(0):6481. 2015-04-22 [PMID: 25901944] (Bioassay, Mouse)	Bioassay	Mouse
Chmilewsky F, Jeanneau C, Laurent P, About I Pulp fibroblasts synthesize functional complement proteins involved in initiating dentin-pulp regeneration. Am J Pathol, 2014-05-09;184(7):1991-2000. 2014-05-09 [PMID: 24814102] (Bioassay, Human)	Bioassay	Human
Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells. J Leukoc Biol, 2014-02-03;95(6):893-901. 2014-02-03 [PMID: 24493825] (Bioassay, Human)	Bioassay	Human
Hoehlig , Kai, Maasch , Christia, Shushakova , Nelli, Buchner , Klaus, Huber-Lang , Markus, Purschke , Werner G, Vater , Axel, Klussmann , Sven A novel C5a-neutralizing mirror-image (l-)aptamer prevents organ failure and improves survival in experimental sepsis. Mol Ther, 2013-07-26;21(12):2236-46. 2013-07-26 [PMID: 23887360] (Surface Plasmon Resonance)	Surface Plasmon Resonance
Liu B, Wei L, Meyerle C, Tuo J, Sen HN, Li Z, Chakrabarty S, Agron E, Chan CC, Klein ML, Chew E, Ferris F, Nussenblatt RB Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration. J Transl Med, 2011-07-15;9(0):111. 2011-07-15 [PMID: 21762495] (Bioassay, Human)	Bioassay	Human
Ruan BH, Li X, Winkler AR, Cunningham KM, Kuai J, Greco RM, Nocka KH, Fitz LJ, Wright JF, Pittman DD, Tan XY, Paulsen JE, Lin LL, Winkler DG Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-alpha production in a receptor for advanced glycation end product-dependent manner. J. Immunol., 2010-09-03;185(7):4213-22. 2010-09-03 [PMID: 20817881] (Binding Assay, Human)	Binding Assay	Human
Truman LA, Ford CA, Pasikowska M, Pound JD, Wilkinson SJ, Dumitriu IE, Melville L, Melrose LA, Ogden CA, Nibbs R, Graham G, Combadiere C, Gregory CD CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood, 2008-09-17;112(13):5026-36. 2008-09-17 [PMID: 18799722] (Bioassay, Human)	Bioassay	Human
Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianflone K, Kohl J, Gerard C, Sarma JV, Ward PA Functional roles for C5a receptors in sepsis. Nat. Med., 2008-05-04;14(5):551-7. 2008-05-04 [PMID: 18454156] (Bioassay, Human)	Bioassay	Human
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Recombinant Human Complement Component C5a Protein

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Catalog# & Formulation	Size	Price
Carrier Free 2037-C5-025/CF

Gene Symbol	C5
Uniprot	P01031()