Recombinant Human CD37 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD37, also known as TSPAN26, is a 40‑45 kDa palmitoylated traspanin superfamily glycoprotein that is mainly expressed by B cell lymphocytes and myeloid cells (1). Tetraspanins are characterized by four transmembrane domains, one small extracellular loop (SEL) and one large extracellular loop (LEL), and short N- and C-termini (1). The CD37-LEL has the most variation across these different domains, but a CCG motif and the position of the last cysteine residue in the LEL are conserved in all tetraspanins (2). Tetraspanins form complexes with a wide range of transmembrane and cytoplasmic proteins, including integrins, forming small networks referred to as tetraspanin enriched microdomains, or TEMs (1). Human CD37-LEL shares 66% amino acid sequence identity with mouse and rat CD37. CD37 directly associates with dectin-1 on macrophages and stabilizes cell surface dectin-1 expression (3). It also inhibits T cell activation and proliferation by limiting T cell receptor signaling (4). Mice deficient in CD37 develop B cell lymphoma (5). Kidneys of CD37^-/- mice showed more mesangial proliferation, endothelial cell activation, podocyte activation, and segmental podocyte foot process effacement compared to the CD37/Il6 double-knockout mice, emphasizing that IL-6 mediates renal pathology in CD37^-/- mice. Thus, CD37 may protect against IgA nephropathy by inhibition of the IL-6 pathway (6).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA.

Showing Publication 1 - 1 of 1.

Publication using 10160-CD	Applications	Species
M de Lourdes, S López-Cisn, V Gutiérrez-, R García-Roc, B Weiss-Stei, J Hernández-, HI Sánchez-Pe, LR Ávila-Ibar, CA Don-López, R Muñóz-Godí, DBT Pineda, R Chacón-Sal, L Vallejo-Ca, SM Pérez-Tapi, A Monroy-Gar HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1 Mediators Inflamm., 2019-05-07;2019(0):4651627. 2019-05-07 [PMID: 31205451] (ELISA, Human)	ELISA	Human

Array 10160-CD

• CD37 Antibodies
• CD37 Lysates
• CD37 Proteins
• CD37 Proteins and Enzyme