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Recombinant Human CCL17/TARC Protein

 (16 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity

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Catalog# & Formulation Size Price
Carrier Free
364-DN-025/CF
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Recombinant Human CCL17/TARC Protein Summary

Details of Functionality
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR4. The ED50 for this effect is 2‑6 ng/mL.
Source
E. coli-derived human CCL17/TARC protein
Ala24-Ser94
Accession #
N-terminal Sequence
Ala24
Protein/Peptide Type
Recombinant Proteins
Gene
CCL17
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity2
Theoretical MW
8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
364-DN in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human CCL17/TARC Protein

  • ABCD-2
  • CC chemokine TARC
  • C-C motif chemokine 17
  • CCL17
  • chemokine (C-C motif) ligand 17
  • MGC138273
  • SCYA17
  • SCYA17MGC138271
  • small inducible cytokine subfamily A (Cys-Cys), member 17
  • Small-inducible cytokine A17
  • T cell-directed CC chemokine
  • TARC
  • TARCA-152E5.3
  • Thymus and activation-regulated chemokine

Background

CCL17 is a novel CC chemokine identified using a signal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (aa)residue precursor protein with a 23 aa residue signal peptide that is cleaved to generate the 71 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24 - 29% amino acid sequence identity with RANTES, MIP-1 alpha , MIP-1 beta , MCP-1, MCP-2, MCP-3 and I-309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL17 was identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells.

  1. Imai, T. et al. (1997) J. Biol. Chem. 272:15036.
  2. Imai, T. et al. (1996) J. Biol. Chem. 271:21514.
  3. Nomiyama, H. et al. (1997) Genomics 40:211.

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Recombinant Human
CCL17/TARC Protein
364-DN
Recombinant Human CCL17/TARC Protein
Species: Hu
Applications: Bioactivity

Publications for CCL17/TARC (364-DN)(16)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Virus.

We have publications tested in 3 applications: Binding Assay, Bioassay, ELISA (Standard).


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Binding Assay
(2)
Bioassay
(11)
ELISA (Standard)
(4)
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Human
(9)
Mouse
(1)
Rat
(1)
Virus
(1)
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Showing Publications 1 - 10 of 16. Show All 16 Publications.
Publications using 364-DN Applications Species
J Okano, Y Nakae, T Nakagawa, M Katagi, T Terashima, D Nagakubo, T Nakayama, O Yoshie, Y Suzuki, H Kojima A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury Scientific Reports, 2021-03-11;11(1):5653. 2021-03-11 [PMID: 33707490] (Bioassay, Human) Bioassay Human
Nakagawa , Masao, Schmitz , Roland, Xiao , Wenming, Goldman , Carolyn, Xu , Weihong, Yang , Yandan, Yu , Xin, Waldmann , Thomas A, Staudt , Louis M Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma. J Exp Med, 2014-12-08;211(13):2497-505. 2014-12-08 [PMID: 25488980] (Bioassay, Mouse) Bioassay Mouse
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human) Bioassay Human
Paantjens AW, van de Graaf EA, Kwakkel-van Erp JM, Hoefnagel T, van Kessel DA, van den Bosch JM, Otten HG Lung transplantation affects expression of the chemokine receptor type 4 on specific T cell subsets. Clin. Exp. Immunol., 2011-10-01;166(1):103-9. 2011-10-01 [PMID: 21910727] (ELISA (Standard)) ELISA (Standard)
Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J. Immunol., 2010-02-17;184(6):2886-98. 2010-02-17 [PMID: 20164417] (Bioassay, Human) Bioassay Human
Liu LY, Bates ME, Jarjour NN, Busse WW, Bertics PJ, Kelly EA Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha. J. Immunol., 2007-10-01;179(7):4840-8. 2007-10-01 [PMID: 17878383] (ELISA (Standard)) ELISA (Standard)
Baatar D, Olkhanud P, Newton D, Sumitomo K, Biragyn A CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors. J. Immunol., 2007-08-01;179(3):1996-2004. 2007-08-01 [PMID: 17641067] (Bioassay, Human) Bioassay Human
Heijink IH, Marcel Kies P, van Oosterhout AJ, Postma DS, Kauffman HF, Vellenga E Der p, IL-4, and TGF-beta cooperatively induce EGFR-dependent TARC expression in airway epithelium. Am. J. Respir. Cell Mol. Biol., 2006-10-05;36(3):351-9. 2006-10-05 [PMID: 17023689] (Bioassay, Human) Bioassay Human
Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J. Immunol., 2006-10-01;177(7):4488-94. 2006-10-01 [PMID: 16982885] (Bioassay, Human) Bioassay Human
Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, Nagakubo D, Saito T, Shimomura Y, Yoshie O Novel antiviral activity of chemokines. Virology, 2006-04-17;350(2):484-92. 2006-04-17 [PMID: 16603217] (Binding Assay, Bioassay, Virus) Binding Assay, Bioassay Virus
Show All 16 Publications.

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Bioinformatics

Gene Symbol CCL17
Uniprot