Recombinant Human Caspr2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Contact-associated Protein-like 2 (Caspr2) is a type I transmembrane member of the neurexin family of adhesion molecules (1). Human Caspr2 is the vertebrate homolog to Drosophila Neurexin IV, and the human and mouse Caspr2 orthologs share 94% amino acid sequence identity. Human Caspr2 contains two EGF-like domains, one F5/8 type C domain, one fibrinogen C-terminal domain, and four laminin G-like domains. It is highly expressed in neuronal tissue where it is primarily localized to the juxtaparanodal region of the axonal membrane (1, 2). Caspr2 acts in conjunction with 4.1B and Tag-1 as a scaffold that clusters Kv1 potassium channels at the juxtaparanodal region and is critical for axo-glial contacts (1-6). Caspr2 interacts with carboxypeptidase E in Golgi bodies during intracellular trafficking to the cell membrane (7). Caspr2 is also required for dendrite arborization and the normal development of neural networks (8). Mutations in Caspr2 are associated with predisposition to autism spectrum disorders, epilepsy, attention-deficit hyperactive disorder, and schizophrenia (8-11). The presence of autoantibodies against Caspr2 is associated with encephalitis, epilepsy, dysarthria, and paroxysmal kinesigenic dystonia (12-14). R&D Systems in-house testing indicates that Caspr2 can enhance bovine corneal endothelial cell adhesion.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA Capture.

Showing Publication 1 - 1 of 1.

Publication using 8207-CR	Applications	Species
P Körtvelyes, A Goihl, K Guttek, B Schraven, H Prüss, D Reinhold Serum and CSF cytokine levels mirror different neuroimmunological mechanisms in patients with LGI1 and Caspr2 encephalitis Cytokine, 2020-08-12;135(0):155226. 2020-08-12 [PMID: 32799011] (ELISA Capture, Human)	ELISA Capture	Human

Array 8207-CR

• Caspr2 Antibodies
• Caspr2 ELISA Kit
• Caspr2 Lysate
• Caspr2 Protein
• Caspr2 Proteins and Enzymes