Recombinant Human Cadherin-10 (CAD-10) Fc Chimera, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cadherin-10, also known as T2-Cadherin, is an approximately 120 kDa type I transmembrane protein belonging to the Cadherin superfamily of calcium-dependent adhesion molecules. Cadherins are involved in multiple processes including embryonic development, cell migration, and maintenance of epithelial integrity (1, 2). Human Cadherin-10 is synthesized with a 22 amino acid (aa) signal peptide and a 32 aa N‑terminal propeptide. The mature cell surface-expressed protein consists of a 559 amino acid (aa) extracellular domain (ECD) that contains five tandem Cadherin repeats, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain (3, 4). Within the propeptide and ECD, human Cadherin-10 shares 97% aa sequence identity with mouse and rat Cadherin-10. It interacts homotypically as well as hetertypically with Cadherin-9 and more weakly with Cadherin-6 (4). Cadherin-10 is expressed in the central nervous system, particularly in the limbic system, frontal cortex, somatosensory barrel cortex (in rat), olfactory structures, epithelial cells lining the choroid plexus and ventricles, retinal pigmented epithelium, and endothelial cells of the brain and retinal microvasculature (3, 5‑10). It is also expressed on epithelial luminal cells of the prostate, as well as in testes, ovary, placenta, kidney, small intestine, and on CD4+CD8+ T cells (3, 10‑13). Cadherin-10 expression is decreased postnatally in the barrel cortex and testes (8, 12). It is also down‑regulated in glioblastoma vasculature and prostate cancer (10, 11). Polymorphisms of human Cadherin-10 are associated with autism spectrum disorders (6).

Array 6770-CA

• Cadherin-10 Antibodies
• Cadherin-10 Proteins and Enzyme