Recombinant Human ADAM28 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

A distintegrin and metalloprotease domain-containing protein 28 (ADAM28), also known as MDC-L, is a member of the M12B peptidase family of enzymes. It is synthesized as an approximately 80-90 kDa glycosylated proprotein that is processed to a mature form later in the secretory pathway (1-3). After the removal of the propeptide that contains a cysteine switch motif, the activated form of ADAM28 consists of a 467 amino acid (aa) extracellular domain (ECD) which contains a peptidase, disintegrin, cysteine-rich and EGF-like domains, followed by a 21 aa transmembrane segment and an 89 aa cytoplasmic domain (3). Alternative splicing generates additional isoforms with a variety of substitutions and deletions in the cysteine-rich and EGF-like domains (1). Within the ECD, human ADAM28 shares 73% aa sequence identity with mouse and rat ADAM28 (3).  ADAM28 is a cell surface protein that is involved in a variety of cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis (4-6), and exhibits catalytic activity to insulin-like growth factor binding protein-3 (7). Like many members of the ADAM proteins, the disintegrin domain of ADAM28 interacts with integrin to influence cell adhesion and cell-cell interaction (8). ADAM28 can mediate the adhesion of the Jurkat cells, T-lymphoma cell line, through integrin alpha 4b1(9). 

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	Binding assay/Protein-protein interaction		08/16/2018	View Summary Application Binding assay/Protein-protein interaction Lot DFDB0516111

Array 9325-AD

• ADAM28 Antibodies
• ADAM28 ELISA Kits
• ADAM28 Lysates
• ADAM28 Protein
• ADAM28 Proteins and Enzyme