Recombinant Cynomolgus/Rhesus NKp30 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

NKp30, also termed Natural cytotoxicity receptor 3 (NCR3), along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors" (1). These receptors play a major role in triggering NK-mediated killing of most tumor cell lines. Mature NKp30 consists of an extracellular domain (ECD) with a V‑type Ig-like fold, a single transmembrane region and a short cytoplasmic domain (2). A charged residue in the transmembrane domain of NKp30 is responsible for association with the tyrosine-based activating motif (ITAM)‑bearing accessory protein CD3 zeta (2). The ECD of cynomologus NKp30 shares 93% amino acid sequence identity with the ECD of human NKp30. In human, several NKp30 isoforms arising from alternative splicing are known to exist (3). NKp30 is expressed on both resting and activated NK cells of the CD56dim, CD16+ subset and account for ~85% of NK cells found in peripheral blood and spleen (4). While NKp30 is absent from the CD56bright, CD16- subset that constitutes the majority of NK cells in lymph node and tonsil, its expression is up-regulated in these cells upon IL-2 activation (4). Studies with neutralizing antibodies reveal that NKp30 is partially responsible for triggering lytic activity against several tumor cell types and that it is the main receptor responsible for NK-mediated lysis of immature dendritic cells (2, 5). The B7 family member B7-H6, a tumor cell ligand, has been identified as activating NKp30 (6). Additionally, soluble galectin-3 released from tumor cells was found to bind NKp30 thereby inhibiting NKp30-mediated cytotoxicity (7).

Array 10947-NK

• NKp30/NCR3 Antibodies
• NKp30/NCR3 Lysate
• NKp30/NCR3 Proteins and Enzymes