Recombinant Canine PD-L1/B7-H1 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Programmed Death Ligand 1 (PD-L1), also known as B7-H1 and CD274, is a transmembrane glycoprotein in the B7 family of immune regulatory molecules. The B7 family is comprised of at least 10, structurally related members, and plays a central role in the regulation of T cell response by eliciting both positive co-stimulatory and negative inhibitory signals (1). Manipulation of B7 mediated signaling has shown potential in the treatment of autoimmunity, inflammatory diseases and cancer (1, 2). Mature PD-L1 consists of 1 IgV-like and 1 IgC-like region in the extracellular domain (ECD), a transmembrane region and a short intracellular domain. The ECD of canine PD-L1 shares 80% and 70% amino acid sequence identity with human and mouse PD-L1, respectively. In humans, alternative splicing can generate additional isoforms that either lack the first Ig-like domain or are truncated within the second Ig-like domain (3). PD-L1 binds to T cell B7-1/CD80 and PD-1 (4). PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, endothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma (4). It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells (5). It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development (5, 6). PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells (5-7). In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells (8).

Array 10746-B7

• PD-L1 Antibodies
• PD-L1 Antibody Pairs
• PD-L1 ELISA Kit
• PD-L1 Lysate
• PD-L1 Proteins
• PD-L1 Proteins and Enzymes
• PD-L1 ELISAs