Rat IL-4 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-4 (Interleukin-4) is a cytokine that is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. The type I receptor for IL-4, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R? and the common ? chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). The type II receptor on nonhematopoietic cells consists of IL-4 R? and IL-13 R?1. The type II receptor also transduces IL-13 mediated signals.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 1 application: ELISA (Standard).

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using R4000	Applications	Species
Zhu, WX;Xi, Y;Li, F;Jiao, WE;Li, ZJ;Chen, SM;Kong, YG;Xu, Y;Deng, YQ;Zuo, JJ;Tao, ZZ; Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1 Heliyon 2023-07-01 [PMID: 37449098] (Rat)		Rat
YX Ma, K Jiao, QQ Wan, J Li, MY Liu, ZB Zhang, W Qin, KY Wang, YZ Wang, FR Tay, LN Niu Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improve in-situ bone regeneration Bioactive materials, 2021-07-27;9(0):475-490. 2021-07-27 [PMID: 34820584] (Rat)		Rat
RVP Neves, HL Corrêa, IV de Sousa N, MK Souza, F Costa, AS Haro, LA Deus, AL Reis, HG Simões, RV Andrade, CO Assumpção, W Stone, J Prestes, EC Vieira, R de Cássia, V Cruzat, TS Rosa Renoprotection Induced by Aerobic Training Is Dependent on Nitric Oxide Bioavailability in Obese Zucker Rats Oxidative Medicine and Cellular Longevity, 2021-09-28;2021(0):3683796. 2021-09-28 [PMID: 34621463] (Rat)		Rat
JD Koerner, DZ Markova, GD Schroeder, BP Calio, A Shah, CW Brooks, AR Vaccaro, DG Anderson, CK Kepler The local cytokine and growth factor response to rhBMP-2 after spinal fusion Spine J, 2018-03-14;0(0):. 2018-03-14 [PMID: 29550606] (ELISA (Standard), Rat)	ELISA (Standard)	Rat
B Nieto-Lima, A Cano-Martí, ME Rubio-Ruiz, I Pérez-Torr, V Guarner-La Age-, Gender-, andin VivoDifferent Doses of Isoproterenol Modifyin VitroAortic Vasoreactivity and Circulating VCAM-1 Front Physiol, 2018-01-24;9(0):20. 2018-01-24 [PMID: 29416512] (Mouse)		Mouse
BG Lania, J Morari, AL Souza, MND Silva, AR de Almeida, G Veira-Dami, SM Alegre, CL César, LA Velloso, ML Cintra, NB Maia, PENF Velho Topical use and systemic action of green and roasted coffee oils and ground oils in a cutaneous incision model in rats (Rattus norvegicus albinus) PLoS ONE, 2017-12-13;12(12):e0188779. 2017-12-13 [PMID: 29236720] (Rat)		Rat
C Honjoh, K Chihara, H Yoshiki, S Yamauchi, K Takeuchi, Y Kato, Y Hida, T Ishizuka, K Sada Association of C-Type Lectin Mincle with Fc?RI?? Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk Sci Rep, 2017-04-10;7(0):46064. 2017-04-10 [PMID: 28393919] (Rat)		Rat
Gao L, Lu Q, Huang L, Ruan L, Yang J, Huang W, ZhuGe W, Zhang Y, Fu B, Jin K, ZhuGe Q Transplanted neural stem cells modulate regulatory T, gammadelta T cells and corresponding cytokines after intracerebral hemorrhage in rats. Int J Mol Sci, 2014-03-13;15(3):4431-41. 2014-03-13 [PMID: 24633197] (Rat)		Rat
Joo H, Nam S, Yang K, Kim C, Jin Y, Kim J The effects of low-dose ionizing radiation in the activated rat basophilic leukemia (RBL-2H3) mast cells. J Biol Chem, 2012-06-14;287(33):27789-95. 2012-06-14 [PMID: 22700973] (Rat)		Rat
Stevenson CS, Docx C, Webster R, Battram C, Hynx D, Giddings J, Cooper PR, Chakravarty P, Rahman I, Marwick JA, Kirkham PA, Charman C, Richardson DL, Nirmala NR, Whittaker P, Butler K Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-08-24;293(5):L1183-93. 2007-08-24 [PMID: 17720875] (Rat)		Rat
de Oliveira AP, Domingos HV, Cavriani G, Damazo AS, Dos Santos Franco AL, Oliani SM, Oliveira-Filho RM, Vargaftig BB, de Lima WT Cellular recruitment and cytokine generation in a rat model of allergic lung inflammation are differentially modulated by progesterone and estradiol. Am. J. Physiol., Cell Physiol., 2007-07-18;293(3):C1120-8. 2007-07-18 [PMID: 17634417] (Rat)		Rat
Gegg ME, Harry R, Hankey D, Zambarakji H, Pryce G, Baker D, Adamson P, Calder V, Greenwood J Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. J. Immunol., 2005-02-15;174(4):2327-35. 2005-02-15 [PMID: 15699169] (Rat)		Rat
Schubert T, Horch RE Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma. Ann. Surg., 2004-08-01;240(2):340-9. 2004-08-01 [PMID: 15273560] (Rat)		Rat
Jeschke MG, Klein D, Bolder U, Einspanier R Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology, 2004-06-10;145(9):4084-93. 2004-06-10 [PMID: 15192048] (Rat)		Rat
de Bernardis F, Santoni G, Boccanera M, Spreghini E, Adriani D, Morelli L, Cassone A Local anticandidal immune responses in a rat model of vaginal infection by and protection against Candida albicans. Infect. Immun., 2000-06-01;68(6):3297-304. 2000-06-01 [PMID: 10816477] (Rat)		Rat
Show All 15 Publications. Collapse Publications.

Array R4000

• IL-4 Antibodies
• IL-4 ELISA Kits
• IL-4 Kit
• IL-4 Proteins
• IL-4 Proteins and Enzymes
• IL-4 ELISAs