PTH1R/PTHR1 Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PTH1 R (Parathyroid hormone receptor # 1; also PTH/PTHr receptor) is a predicted 66‑68 kDa member of the G-protein coupled receptor family # 2. It is expressed on a variety of cell types, including hepatocytes, renal epithelium, smooth muscle cells, and osteoblasts plus chondrocytes. PTH1 R is a receptor for both PTH and PTHrP, and PTH binding promotes Ca⁺⁺-release from bone, mediated by osteoclast formation. Mature human PTH1 R is a 7-transmembrane glycoprotein 567 amino acids (aa) in length. It contains a long, ligand-binding N‑terminal extracellular region (aa 27‑188) and a 130 aa cytoplasmic C-terminal domain. Single aa changes such as Gly121Glu, Ala122Thr and Arg255His can impair PTH1 R signaling. Over aa 1‑189, human PTH1 R shares 88% aa identity with mouse PTH1 R.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array BAF5709

• PTH1R/PTHR1 Antibodies
• PTH1R/PTHR1 ELISA Kits
• PTH1R/PTHR1 Lysate
• PTH1R/PTHR1 Proteins
• PTH1R/PTHR1 Proteins and Enzyme