Proprotein Convertase 2/PCSK2 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Proprotein Convertase 2 (PCSK2) is a subtilisin-like serine peptidase that processes proteins into biologically active products in the secretory pathway. Like other furin/kexin family members, PCSK2 cleaves its substrates primarily after sites of paired basic amino acid residues (1). Autoactivation of PCSK2 occurs in a post‑Golgi compartment of the secretory system (2). Interaction with the secretory protein 7B2 is required for proper activation of PCSK2 (3). The N-terminal domain of 7B2 stabilizes active PCSK2, and a C-terminal fragment of 7B2 can inhibit PCSK2 activity (4). rhPCSK2 was coexpressed with 7B2 to facilitate activation of the enzyme. PCSK2 is a major proteolytic processing enzyme of the regulated secretory pathway of the neuroendocrine system, where it generates a number of hormones and neuropeptides (5). Products of PCSK2 processing include enkephalins, insulin, somatostatin, dynorphin, and LHRH. Within the region used as an immunogen, human PCSK2 shares 97% aa identity with mouse PCSK2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC.

Showing Publications 1 - 2 of 2.

Publications using AF6018	Applications	Species
J Liu, JDS Reggiani, MA Laboulaye, S Pandey, B Chen, JLR Rubenstein, A Krishnaswa, JR Sanes Tbr1 instructs laminar patterning of retinal ganglion cell dendrites Nat. Neurosci., 2018-04-09;0(0):. 2018-04-09 [PMID: 29632360] (IHC, Mouse)	IHC	Mouse
Hiroyuki Yamamoto, Bruno Ramos-Molina, Adam N. Lick, Matthew Prideaux, Valeria Albornoz, Lynda Bonewald et al. Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition Bone 3/1/2016 [PMID: 26746780]

Array AF6018

• Proprotein Convertase 2/PCSK2 Antibodies
• Proprotein Convertase 2/PCSK2 ELISA Kits
• Proprotein Convertase 2/PCSK2 Lysate
• Proprotein Convertase 2/PCSK2 Protein
• Proprotein Convertase 2/PCSK2 Proteins and Enzyme