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Progesterone R/NR3C3 Antibody

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Immunohistochemistry-Paraffin: Progesterone R/NR3C3 Antibody [NBP1-87776] - Analysis in human endometrium and tonsil tissues using NBP1-87776 antibody. Corresponding PGR RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Progesterone R/NR3C3 Antibody [NBP1-87776] - Staining of human endometrium shows strong nuclear positivity in glandular cells.
Immunohistochemistry-Paraffin: Progesterone R/NR3C3 Antibody [NBP1-87776] - Staining of human fallopian tube shows strong nuclear positivity in glandular cells.
Immunohistochemistry-Paraffin: Progesterone R/NR3C3 Antibody [NBP1-87776] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
Immunohistochemistry-Paraffin: Progesterone R/NR3C3 Antibody [NBP1-87776] - Staining of human tonsil shows no positivity in non-germinal center cells as expected.
Independent Antibodies: Staining of human endometrium, fallopian tube, pancreas and tonsil using NBP1-87776 (A) shows similar protein distribution across tissues to independent antibody NBP1-87774 (B).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
 

Independent Antibodies

       

Order Details

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Progesterone R/NR3C3 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: LLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPL
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PGR
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
Progesterone R/NR3C3 Recombinant Protein Antigen (NBP1-87776PEP)
Publications
Read Publication using NBP1-87776.

Reactivity Notes

Reactivity reported in scientific literature (PMID: 23777659)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Progesterone R/NR3C3 Antibody

  • NR3C3
  • NR3C3PRNuclear receptor subfamily 3 group C member 3
  • PGR
  • Progesterone R
  • progesterone receptor
  • ProgesteroneR

Background

The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Progesterone R/NR3C3 Antibody (NBP1-87776)(1)

Reviews for Progesterone R/NR3C3 Antibody (NBP1-87776) (0)

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Product General Protocols

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FAQs for Progesterone R/NR3C3 Antibody (NBP1-87776). (Showing 1 - 1 of 1 FAQ).

  1. I am interested in getting antibodies for PR (progesterone receptor) that would work in flow cytometry. Could you recommend some choices?
    • We do not currently have any antibodies directed towards the progesterone receptor that have been validated in flow cytometry, but any of our antibodies that work in ICC should work just fine in flow as they are essentially the same application. Please see this link for our Progesterone Receptor antibodies validated in ICC.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PGR