Pref-1/DLK1/FA1 Antibody (211309)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Pref-1 (Preadipocyte factor 1; also DLK-1 and FA1) is a 58-65 kDa member of the Notch/Serrata/Delta family of proteins.  It is expressed in prechondrocytes and preadipocytes and appears to block progenitor cell differentiation into mature cell lineages.  Mature human Pref-1 is a 360 amino acid (aa) type I transmembrane N- and O-linked glycoprotein.  It contains a 280 aa extracellular region (aa 24-303), a 24 aa transmembrane segment (aa 304-327), and a 56 aa cytoplasmic domain (aa 328-383).  The extracellular region contains six EGF-like domains, and undergoes proteolytic cleavage to generate a bioactive 50 kDa fragment, plus three 25‑31 kDa fragments that show no activity.  There are multiple potential splice variants.  One shows a deletion of aa 229-301, a second possesses a six aa substitution for aa 1‑52, a third shows a deletion of aa 210-277, while a fourth contains a six aa substitution for aa 207-383.  Over aa 24-297, human Pref-1 shares 82% aa identity with mouse Pref-1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: ICC, IHC, Immunoprecipitation, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using MAB1144	Applications	Species
X Luo, Y Li, P Yang, Y Chen, L Wei, T Yu, J Xia, XZ Ruan, L Zhao, Y Chen Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function EBioMedicine, 2020-06-06;56(0):102797. 2020-06-06 [PMID: 32516742] (IHC, Human)	IHC	Human
JC Gerlach, RL Thompson, B Gridelli, E Schmelzer Effects of Delta-Like Noncanonical Notch Ligand 1 Expression of Human Fetal Liver Hepatoblasts on Hematopoietic Progenitors Stem Cells Int, 2019-03-18;2019(0):7916275. 2019-03-18 [PMID: 31011334] (IHC, Human)	IHC	Human
Ulrich F, Carretero-Ortega J, MenEndez J et al. Reck enables cerebrovascular development by promoting canonical Wnt signaling Development. 12/31/2015 [PMID: 26657775]
Begum A, Lin Q, Yu C, Kim Y, Yun Z Interaction of delta-like 1 homolog (Drosophila) with prohibitins and its impact on tumor cell clonogenicity. Mol Cancer Res, 2013-11-18;12(1):155-64. 2013-11-18 [PMID: 24249679] (ICC, Immunoprecipitation, Human)	ICC, Immunoprecipitation	Human
Kim Y, Lin Q, Zelterman D, Yun Z Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity. Cancer Res., 2009-12-15;69(24):9271-80. 2009-12-15 [PMID: 19934310] (ICC, Human)	ICC	Human
Chung S, Lapoint K, Martinez K, Kennedy A, Boysen Sandberg M, McIntosh MK Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology, 2006-07-27;147(11):5340-51. 2006-07-27 [PMID: 16873530] (ICC, Western Blot, Human)	ICC, Western Blot	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Ming Lu	Flow	Human	01/09/2018	View Summary Application Flow Cytometry Sample Tested NIH3T3 cells overxpressing human DLK1 Species Human Lot 1YH0415091

Array MAB1144

• Pref-1/DLK1/FA1 Antibodies
• Pref-1/DLK1/FA1 ELISA Kit
• Pref-1/DLK1/FA1 Lysate
• Pref-1/DLK1/FA1 Proteins
• Pref-1/DLK1/FA1 Proteins and Enzymes
• Pref-1/DLK1/FA1 ELISA