PLK1 Antibody

Polo related kinase (PLK), a serine/threonine kinase is strongly correlated with the mitotic activity of cells. PLK is present in all tissues during mouse embryonic development, where as in adults expresion is limited to thymus and ovaries. It has been observed that tumors of various origin (lung, colon, stomach, smooth muscle, and esophagus as well as non-Hodgkin lymphomas) express high levels of PLK transcripts with absent of transcripts in normal surrounding tissues. Only normal colon and placenta, which are known to be mitotically active express PLK. PLK expression is restricted to proliferating cells. In mammalian cells, three PLKs (PLK1, PLK2/Snk, PLK3/Fnk) have been identified. PLK1 is the most studied isoform. The known substrates of PLK1 include several proteins involved in mitosis such as Cdc25C, APC, and cyclin B. PLK1 promotes mitosis through the phosphorylation and activation of Cdc25C, which regulates the tyrosine dephosphorylation of CDKs.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF, WB.

Showing Publication 1 - 1 of 1.

Publication using NB100-56651	Applications	Species
Morris Edward J, Kawamura Eiko, Gillespie Jordan A et al. Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1. Nature Communications 2017-05-05 [PMID: 28474672] (IF, WB, Human)	IF, WB	Human

Array NB100-56651

• PLK1 Antibodies
• PLK1 Lysate
• PLK1 Proteins
• PLK1 Proteins and Enzyme