PIF1 Antibody [DyLight 405]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

PIF1 (pre-implantation factor, PIF1 5'-to-3' DNA helicase homolog, PIF, PIF1/RRM3 DNA helicase-like protein, C15orf20) is a member of the helicase family associated with embryo association with the uterus. PIF1 is also a DNA dependent ATPase that negatively regulates telomerase, the reverse transcriptase that affects telomere length (PMID 16522649). PIF1 is expressed in the nucleus in the late S/G2 phase and is carefully regulated by the cell cycle. In human tumor cells, the deletion of the PIF1 gene reduces the survival of both the p53-deficient and p53-proficient cells by initiating apoptosis by blocking S-phase entry and progression (PMID 21616935). Acting as a G4 resolvase, PIF1 prevents the formation of G4 (G-quadruplex) structures by stabilizing DNA sequences (PMID 20524933).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-97931V

• PIF1 Antibodies
• PIF1 Lysate
• PIF1 Protein