PEX5 Antibody

The product of the PEX5 gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP1-87185	Applications	Species
Fu X, Wan P, Lu L et al. Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023-05-12 [PMID: 37171794] (IHC, WB, Mouse)	IHC, WB	Mouse
Balakrishnan A, Adnani L, Chinchalongporn V et al. SMPD3-mediated extracellular vesicle biogenesis inhibits oligodendroglioma growth bioRxiv 2020-07-15 (WB)	WB
Chen BH, Chang YJ, Lin S, Yang WY Hsc70/Stub1 promotes the removal of individual oxidatively stressed peroxisomes Nat Commun 2020-10-19 [PMID: 33077711] (WB, Mouse)	WB	Mouse
Balakrishnan A Glial cells in health and disease Thesis 2020-01-01 (WB, Human)	WB	Human

Array NBP1-87185

• PEX5 Antibodies
• PEX5 Lysate
• PEX5 Proteins