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Osteoactivin/GPNMB Antibody (glembatumumab) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, Func
Clone
glembatumumab
Clonality
Monoclonal
Host
Human
Conjugate
Janelia Fluor 549

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Osteoactivin/GPNMB Antibody (glembatumumab) [Janelia Fluor® 549] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
GPNMB
Isotype
IgG2
Clonality
Monoclonal
Host
Human
Gene
GPNMB
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Functional
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Osteoactivin/GPNMB Antibody (glembatumumab) [Janelia Fluor® 549]

  • DC-HIL
  • glycoprotein (transmembrane) nmb
  • glycoprotein NMB
  • GPNMB
  • HGFIN
  • HGFINglycoprotein nmb-like protein
  • NMBosteoactivin
  • Osteoactivin
  • Transmembrane glycoprotein HGFIN
  • transmembrane glycoprotein NMB

Background

The GPNMB gene codes for a type I transmembrane glycoprotein NBM. The GPNMB gene is present in lowly, but not highly, metastic human melanoma cell lines, therefore, it demonstrates involvement in development, proliferation, and differentiation of tissues. Isoform 1 is 572 amino acids long at a mass of nearly 64 kDA and isoform 2 exists at 560 amino acids long at approximately 62 kDA. This gene has been known to interact with various genes such as SMAD4, PLA2G4A, and ITSN2. GPNMB has been researched in its role in retinitis, lung cancer, melanoma, glioblastoma, glaucoma, and breast cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GPNMB