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Osteoactivin/GPNMB Antibody (glembatumumab) - IgG2SA

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Immobilized human GPNMB his at 2 ug/mL can bind Osteoactivin/GPNMB Antibody (glembatumumab) - IgG2SA , EC50=0.01720 ug/mL.
Immobilized human GPNMB his at 2 ug/mL can bind Osteoactivin/GPNMB Antibody (glembatumumab) - IgG2SA , EC50=0.01720 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, Func
Clone
glembatumumab
Clonality
Monoclonal
Host
Human
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-28144AF350
Alexa Fluor 405
NBP3-28144AF405
Alexa Fluor 488
NBP3-28144AF488
Alexa Fluor 532
NBP3-28144AF532
Alexa Fluor 594
NBP3-28144AF594
Alexa Fluor 647
NBP3-28144AF647
Alexa Fluor 700
NBP3-28144AF700
Alexa Fluor 750
NBP3-28144AF750
Allophycocyanin
NBP3-28144APC
Biotin
NBP3-28144B
CoraFluor 1
NBP3-28144CL1
DyLight 350
NBP3-28144UV
DyLight 405
NBP3-28144V
DyLight 488
NBP3-28144G
DyLight 550
NBP3-28144R
DyLight 594
NBP3-28144DL594
DyLight 650
NBP3-28144C
DyLight 680
NBP3-28144FR
DyLight 755
NBP3-28144IR
FITC
NBP3-28144F
HRP
NBP3-28144H
Janelia Fluor 525
NBP3-28144JF525
Janelia Fluor 549
NBP3-28144JF549
Janelia Fluor 646
NBP3-28144JF646
Janelia Fluor 669
NBP3-28144JF669
PE
NBP3-28144PE
PerCP
NBP3-28144PCP
mFluor Violet 450 SE
NBP3-28144MFV450
mFluor Violet 500 SE
NBP3-28144MFV500
mFluor Violet 610 SE
NBP3-28144MFV610
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Osteoactivin/GPNMB Antibody (glembatumumab) - IgG2SA Summary

Description
Expressed from CHO. The heavy chain type is huIgG2, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Also known as 'glembatumumab'.

IgG2SA is human IgG2 with S378A mutation.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
GPNMB
Isotype
IgG2
Clonality
Monoclonal
Host
Human
Gene
GPNMB
Purity
Protein A purified
Endotoxin Note
< 0.001EU/ug,determined by LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Functional

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A purified
Reconstitution Instructions
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for Osteoactivin/GPNMB Antibody (glembatumumab) - IgG2SA

  • DC-HIL
  • glycoprotein (transmembrane) nmb
  • glycoprotein NMB
  • GPNMB
  • HGFIN
  • HGFINglycoprotein nmb-like protein
  • NMBosteoactivin
  • Osteoactivin
  • Transmembrane glycoprotein HGFIN
  • transmembrane glycoprotein NMB

Background

The GPNMB gene codes for a type I transmembrane glycoprotein NBM. The GPNMB gene is present in lowly, but not highly, metastic human melanoma cell lines, therefore, it demonstrates involvement in development, proliferation, and differentiation of tissues. Isoform 1 is 572 amino acids long at a mass of nearly 64 kDA and isoform 2 exists at 560 amino acids long at approximately 62 kDA. This gene has been known to interact with various genes such as SMAD4, PLA2G4A, and ITSN2. GPNMB has been researched in its role in retinitis, lung cancer, melanoma, glioblastoma, glaucoma, and breast cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GPNMB
Uniprot