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NPRA/NPR1 Antibody (488620) [Unconjugated]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications IHC
Clone
488620
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB3974-SP
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NPRA/NPR1 Antibody (488620) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse NPRA/NPR1
Ser29-Glu469 (predicted)
Accession # P18293
Specificity
Detects mouse NPRA/NPR1 in direct ELISAs.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
NPR1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL
Publications
Read Publication using MAB3974.

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NPRA/NPR1 Antibody (488620) [Unconjugated]

  • ANPa
  • ANP-A
  • ANPRA
  • ANPR-A
  • ANPRAEC 4.6.1.2
  • atrial natriuretic peptide receptor 1
  • Atrial natriuretic peptide receptor type A
  • atrionatriuretic peptide receptor A
  • GC-A
  • Guanylate cyclase A
  • GUC2A
  • GUCY2A
  • natriuretic peptide A type receptor
  • natriuretic peptide receptor A
  • natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptidereceptor A)
  • NPR1
  • NPRA
  • NPR-A
  • Pndr

Background

Mouse NPR1 (natriuretic peptide receptor-1; also ANP-R1 or guanlyl cyclase-A) is a 130 kDa member of the guanylyl cyclase family of proteins. It is a type I transmembrane glycoprotein that contains a 441 aa extracellular domain (ECD) (aa 29‑469) and a 567 aa cytoplasmic region. The cytoplasmic region shows a tyrosine kinase and guanylyl cyclase catalytic domain. NPR1 operates as an oligomer and binds both ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide). ANP binding induces bronchodilation and a reduction in blood pressure. Over aa 29‑469, mouse NPR1 is 97% and 86% aa identical to rat and human NPR1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NPR1
Uniprot