NPRA/NPR1 Products

Description

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 (PubMed 7982997)). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).(supplied by OMIM)

Bioinformatics

Uniprot	AAH63304 Human NM_000906 Human NP_000897 Human
Product By Gene ID	4881
Alternate Names	ANPa ANP-A ANPR-A ANPRAEC 4.6.1.2 atrial natriuretic peptide receptor 1 Atrial natriuretic peptide receptor type A atrionatriuretic peptide receptor A GC-A Guanylate cyclase A GUC2A GUCY2A natriuretic peptide A type receptor natriuretic peptide receptor A natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptidereceptor A) NPRA NPR-A

Research Areas for NPRA/NPR1

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Protein Kinase