Nogo-A Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Nogo-A, also known as Reticulon-4, is the longest of four splice variants of Nogo. It is a CNS myelin-associated neurite outgrowth inhibitor that is highly expressed in oligodendrocytes. Nogo-A is synthesized as an 1163 amino acid protein and lacks a signal peptide. Within conserved C-terminal reticulon homology domain (RHD), two transmembrane domains, which are separated by a 66 amino acid extracellular loop, exist. Both the N-terminal domain and the 66 amino acid domain (Nogo-66) can be detected on the cell surface and show neurite outgrowth inhibitory activity. The amino acid sequence of rat Nogo-A N-terminal domain is 76% identical to that of human Nogo-A. Within the RHD domain, rat Nogo-A shares 99% and 97% amino acid sequence identity with mouse and human Nogo, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 5 of 5.

Publications using AF3098	Applications	Species
Daniela Talhada, Niklas Marklund, Tadeusz Wieloch, Enida Kuric, Karsten Ruscher Plasticity-Enhancing Effects of Levodopa Treatment after Stroke International Journal of Molecular Sciences 2021-09-23 [PMID: 34638567]
Y Sekine, JA Lindborg, SM Strittmatt A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration Nat. Med., 2019-11-20;295(8):2175-2183. 2019-11-20 [PMID: 31748413] (Western Blot, Human)	Western Blot	Human
Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1beta release through the inhibition of Nogo-A expression. J Neuroinflammation, 2012-06-07;9(0):121. 2012-06-07 [PMID: 22676811] (Western Blot, Rat)	Western Blot	Rat
Raiker SJ, Lee H, Baldwin KT Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. J. Neurosci., 2010-09-15;30(37):12432-45. 2010-09-15 [PMID: 20844138] (Western Blot, Mouse)	Western Blot	Mouse
Robak LA, Venkatesh K, Lee H, Raiker SJ, Duan Y, Lee-Osbourne J, Hofer T, Mage RG, Rader C, Giger RJ Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition. J. Neurosci., 2009-05-06;29(18):5768-83. 2009-05-06 [PMID: 19420245] (Western Blot, Rat)	Western Blot	Rat

Array AF3098

• Nogo-A Antibodies
• Nogo-A Proteins and Enzymes