NKG2C/CD159c/KLRC2 Antibody (134591) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins. Natural killer (NK) receptors are expressed in both NK cells and cytotoxic CD8⁺ T cells and have both activating and inhibitory members (1-3). Regulation of the balance between the activating and inhibitory receptors is important and lack of such regulation has been implicated in autoimmunity (4). The NKG2 family includes seven receptors: NKG2A, -B, -C, -D, -E, -F, and -H, which is the longer isoform of NKG2E. Except for NKG2D and NKG2F, the NKG2 family members form heterodimers with CD94 (5, 6). NKG2C interacts with the adapter molecule DAP12 and acts as activating receptor when heterodimerized with CD94 (7). Human NKG2C is synthesized as a 231 amino acid (aa) protein that includes a 70 aa cytoplasmic domain, a 23 aa transmembrane segment, and a 138 aa extracellular domain (ECD). Within the ECD, human NKG2C shares 40% sequence identity with mouse NKG2C. NKG2C-CD94 heterodimers bind to the widely expressed nonclassical MHC-I molecule, HLA-E (Qa-1b in mouse), which presents a peptide derived from the signal peptide of classical MHC-I molecules (8, 9). Triggering the NKG2C-CD94 complex may activate the cytolytic activity and cytokine production of NK and CD8⁺ T cells (8, 10). Human cytomegalovirus (HCMV) infection promotes the differentiation and expansion of NKG2C⁺ NK cell subsets, possibly involving a cognate interaction of CD94/NKG2C with ligand(s) displayed by HCMV‑infected cells (11, 12).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, Functional Assay.

Showing Publications 1 - 10 of 22. Show All 22 Publications. Collapse Publications.

Publications using MAB138	Applications	Species
d'Angelo, P;Zavaglio, F;Gabanti, E;Zelini, P;Fornara, C;Bernuzzi, S;Spinillo, A;Lilleri, D;Baldanti, F; Evaluation of the In Vitro Capacity of Anti-Human Cytomegalovirus Antibodies to Initiate Antibody-Dependent Cell Cytotoxicity Microorganisms 2024-07-02 [PMID: 39065122] (Flow Cytometry, Human)	Flow Cytometry	Human
HR Wagstaffe, O Anzala, H Kibuuka, Z Anywaine, SB Sirima, R Thiébaut, L Richert, Y Levy, C Lacabaratz, V Bockstal, K Luhn, M Douoguih, MR Goodier NK Cell Subset Redistribution and Antibody Dependent Activation after Ebola Vaccination in Africans Vaccines, 2022-05-31;10(6):. 2022-05-31 [PMID: 35746491] (Flow Cytometry, Human)	Flow Cytometry	Human
L Jiang, H Fei, X Jin, X Liu, C Yang, C Li, J Chen, A Yang, J Zhu, H Wang, X Fei, S Zhang Extracellular Vesicle-Mediated Secretion of HLA-E by Trophoblasts Maintains Pregnancy by Regulating the Metabolism of Decidual NK Cells International journal of biological sciences, 2021-10-22;17(15):4377-4395. 2021-10-22 [PMID: 34803505] (Flow Cytometry, Human)	Flow Cytometry	Human
GM Wiedemann, EK Santosa, S Grassmann, S Sheppard, JB Le Luduec, NM Adams, C Dang, KC Hsu, JC Sun, CM Lau Deconvoluting global cytokine signaling networks in natural killer cells Nature Immunology, 2021-04-15;0(0):. 2021-04-15 [PMID: 33859404] (Flow Cytometry, Human)	Flow Cytometry	Human
D Brownlie, M Scharenber, JE Mold, J Hård, E Kekäläinen, M Buggert, S Nguyen, JN Wilson, M Al-Ameri, HG Ljunggren, N Marquardt, J Michaëlsso Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood Proceedings of the National Academy of Sciences of the United States of America, 2021-03-16;118(11):. 2021-03-16 [PMID: 33836578] (Flow Cytometry, Human)	Flow Cytometry	Human
DR Makanga, T Guillaume, C Willem, N Legrand, K Gagne, A Cesbron, K Gendzekhad, P Peterlin, A Garnier, A Le Bourgeo, MC Béné, P Chevallier, C Retière Posttransplant Cyclophosphamide and Antithymocyte Globulin versus Posttransplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis for Peripheral Blood Stem Cell Haploidentical Transplants: Comparison of T Cell and NK Effector Reconstitution J. Immunol., 2020-08-03;0(0):. 2020-08-03 [PMID: 32747504] (Flow Cytometry, Human)	Flow Cytometry	Human
EM Comeau, KA Holder, NJ Fudge, MD Grant Cytomegalovirus-Driven Adaption of Natural Killer Cells in NKG2Cnull Human Immunodeficiency Virus-Infected Individuals Viruses, 2019-03-09;11(3):. 2019-03-09 [PMID: 30857329] (Flow Cytometry, Human)	Flow Cytometry	Human
B Müller-Dur, J Grählert, OP Devine, AN Akbar, C Hess CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age Aging (Albany NY), 2019-01-27;11(2):724-740. 2019-01-27 [PMID: 30686790] (Flow Cytometry, Human)	Flow Cytometry	Human
G Martrus, T Kautz, S Lunemann, L Richert, L Glau, W Salzberger, H Goebels, A Langenecke, L Hess, T Poch, C Schramm, KJ Oldhafer, M Koch, E Tolosa, B Nashan, M Altfeld Proliferative capacity exhibited by human liver-resident CD49a+CD25+ NK cells PLoS ONE, 2017-08-09;12(8):e0182532. 2017-08-09 [PMID: 28792982] (Flow Cytometry, Human)	Flow Cytometry	Human
Raphaëlle Riou Severe symptomatic primary HCMV infection despite effective innate and adaptive immune responses J. Virol, 2017-02-14;0(0):. 2017-02-14 [PMID: 28031361] (Flow Cytometry, Human)	Flow Cytometry	Human
Huijskens M, Walczak M, Sarkar S, Atrafi F, Senden-Gijsbers B, Tilanus M, Bos G, Wieten L, Germeraad W Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy. Cytotherapy, 2015-03-05;17(5):613-20. 2015-03-05 [PMID: 25747742] (Flow Cytometry, Human)	Flow Cytometry	Human
Marquardt N, Beziat V, Nystrom S, Hengst J, Ivarsson M, Kekalainen E, Johansson H, Mjosberg J, Westgren M, Lankisch T, Wedemeyer H, Ellis E, Ljunggren H, Michaelsson J, Bjorkstrom N Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol, 2015-02-11;194(6):2467-71. 2015-02-11 [PMID: 25672754] (Flow Cytometry, Human)	Flow Cytometry	Human
Nachmani D, Zimmermann A, Oiknine Djian E, Weisblum Y, Livneh Y, Khanh Le V, Galun E, Horejsi V, Isakov O, Shomron N, Wolf D, Hengel H, Mandelboim O MicroRNA editing facilitates immune elimination of HCMV infected cells. PLoS Pathog, 2014-02-27;10(2):e1003963. 2014-02-27 [PMID: 24586166] (Flow Cytometry, Human)	Flow Cytometry	Human
Saghafian-Hedengren S, Sohlberg E, Theorell J, Carvalho-Queiroz C, Nagy N, Persson J, Nilsson C, Bryceson Y, Sverremark-Ekstrom E Epstein-Barr virus coinfection in children boosts cytomegalovirus-induced differentiation of natural killer cells. J Virol, 2013-10-02;87(24):13446-55. 2013-10-02 [PMID: 24089567] (Flow Cytometry, Human)	Flow Cytometry	Human
Charoudeh H, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection. Eur J Immunol, 2012-12-12;43(2):480-7. 2012-12-12 [PMID: 23161492] (Flow Cytometry, Human)	Flow Cytometry	Human
Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. PLoS Pathog., 2012-01-12;8(1):e1002486. 2012-01-12 [PMID: 22253598] (Flow Cytometry, Human)	Flow Cytometry	Human
Angelini DF, Zambello R, Galandrini R, Diamantini A, Placido R, Micucci F, Poccia F, Semenzato G, Borsellino G, Santoni A, Battistini L NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease. J. Leukoc. Biol., 2010-10-15;89(1):75-84. 2010-10-15 [PMID: 20952657] (Flow Cytometry, Functional Assay, Human)	Flow Cytometry, Functional Assay	Human
Beziat V, Descours B, Parizot C, Debre P, Vieillard V NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs. PLoS ONE, 2010-08-06;5(8):e11966. 2010-08-06 [PMID: 20700504] (Flow Cytometry, Human)	Flow Cytometry	Human
Yu J, Mao HC, Wei M, Hughes T, Zhang J, Park IK, Liu S, McClory S, Marcucci G, Trotta R, Caligiuri MA CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets. Blood, 2009-11-06;115(2):274-81. 2009-11-06 [PMID: 19897577] (Flow Cytometry, Human)	Flow Cytometry	Human
Beziat V, Nguyen S, Lapusan S, Hervier B, Dhedin N, Bories D, Uzunov M, Boudifa A, Trebeden-Negre H, Norol F, Marjanovic Z, Marie JP, Vernant JP, Debre P, Rio B, Vieillard V Fully functional NK cells after unrelated cord blood transplantation. Leukemia, 2009-01-08;23(4):721-8. 2009-01-08 [PMID: 19151772] (Flow Cytometry, Human)	Flow Cytometry	Human
Dutertre CA, Bonnin-Gelize E, Pulford K, Bourel D, Fridman WH, Teillaud JL A novel subset of NK cells expressing high levels of inhibitory FcgammaRIIB modulating antibody-dependent function. J. Leukoc. Biol., 2008-08-21;84(6):1511-20. 2008-08-21 [PMID: 18719017] (Flow Cytometry, Human)	Flow Cytometry	Human
de Matos CT, Berg L, Michaelsson J, Fellander-Tsai L, Karre K, Soderstrom K Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion. Immunology, 2007-05-22;122(2):291-301. 2007-05-22 [PMID: 17521371] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 22 Publications. Collapse Publications.

Array MAB138

• NKG2C/CD159c/KLRC2 Antibodies
• NKG2C/CD159c/KLRC2 Lysate
• NKG2C/CD159c/KLRC2 Proteins
• NKG2C/CD159c/KLRC2 Proteins and Enzyme