Neurofibromin 1 Antibody (McNFn27b) - BSA Free

Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. Besides JMML, defects in NF1 have also been linked to neurofibromatosis type 1 (NF1), Watson syndrome (WS), familial spinal neurofibromatosis (FSNF), neurofibromatosis-Noonan syndrome (NFNS), colorectal cancer (CRC).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IF/IHC, IHC-P.

Showing Publications 1 - 2 of 2.

Publications using NB300-154	Applications	Species
Hisaoka M, Hashimoto H, Ohguri T et al. Congenital (infantile) pseudarthrosis of the fibula associated with osteofibrous dysplasia. Skeletal Radiol;33(9):545-9. 2004-09-01 [PMID: 15258702] (IF/IHC, Human)	IF/IHC	Human
Kuorilehto T, Nissinen M, Koivunen J et al. NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos. J Bone Miner Res. 2004-06-01 [PMID: 15125795] (IHC-P, Mouse)	IHC-P	Mouse

Array NB300-154

• Neurofibromin 1 Antibodies
• Neurofibromin 1 Proteins