Neurocan Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neurocan is a 220 kDa nervous tissue-specific chondroitin sulfate proteoglycan member of the aggrecan/versican proteoglycan family (1). Mouse Neurocan is synthesized as a 1268 amino acid (aa) precursor that contains a 22 aa signal sequence and a 1246 aa mature chain. The mature chain contains one Ig-like V-type domain (aa 37-157), two Link domains (aa 159-254 and 258-356), two EGF-like domains (aa 960-996 and 998-1034), one C-type lectin-like domain (aa 1036-1165), one Sushi domain (aa 1165-1224), and five potential sites for N-linked glycosylation. Mature mouse Neurocan is 90% and 66% aa identical to mature rat and human Neurocan, respectively. Neurocan binds with high affinity to the cell adhesion molecules (CAM) Ng-CAM and N-CAM to inhibit Neuronal adhesion and neurite growth (2-3). In the developing rat retina, the expression of Neurocan is regulated both temporally and spatially, which suggests that it may play a role in the differentiation of and neural network formation of the mammalian retina (1). Injury to the CNS leads to permanent loss of function due to the inability of severed nerve fibers to regenerate back to their targets (4). The lack of CNS repair is attributed in part to the extracellular matrix chondroitin sulfate proteoglycans, such as Neurocan, which are produced by activated glial cells post-injury (4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using BAF5800	Applications	Species
Craig S. Pearson, Andrea G. Solano, Sharada M. Tilve, Caitlin P. Mencio, Keith R. Martin, Herbert M. Geller Spatiotemporal distribution of chondroitin sulfate proteoglycans after optic nerve injury in rodents Experimental Eye Research 2020-01-01 [PMID: 31705897]
Jae-Hyuk Yi, Yasuhiro Katagiri, Bala Susarla, David Figge, Aviva J. Symes, Herbert M. Geller Alterations in sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in mice The Journal of Comparative Neurology 2012-10-15 [PMID: 22628090]

Array BAF5800

• Neurocan Antibodies
• Neurocan Protein
• Neurocan Proteins and Enzymes