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NEU-1/Sialidase-1 Antibody (OTI3D4)

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Western Blot: NEU-1/Sialidase-1 Antibody (3D4) [NBP2-46152] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NEU1.
Western Blot: NEU-1/Sialidase-1 Antibody (3D4) [NBP2-46152] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NEU1.
Immunohistochemistry: NEU-1/Sialidase-1 Antibody (3D4) [NBP2-46152] - Analysis of Carcinoma of Human bladder tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
Immunohistochemistry: NEU-1/Sialidase-1 Antibody (3D4) [NBP2-46152] - Analysis of Carcinoma of Human lung tissue.(Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
Immunohistochemistry: NEU-1/Sialidase-1 Antibody (3D4) [NBP2-46152] - Analysis of Adenocarcinoma of Human colon tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
Immunohistochemistry: NEU-1/Sialidase-1 Antibody (3D4) [NBP2-46152] - Analysis of Human liver tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
Immunohistochemistry: NEU-1/Sialidase-1 Antibody (3D4) [NBP2-46152] - Analysis of Human pancreas tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
Immunohistochemistry: NEU-1/Sialidase-1 Antibody (3D4) [NBP2-46152] - Analysis of Carcinoma of Human liver tissue.(Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
Immunohistochemistry: NEU-1/Sialidase-1 Antibody (3D4) [NBP2-46152] - Analysis of Adenocarcinoma of Human breast tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
Immunohistochemistry: NEU-1/Sialidase-1 Antibody (3D4) [NBP2-46152] - Analysis of Human Kidney tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
OTI3D4
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-72942AF350
Alexa Fluor 405
NBP2-72942AF405
Alexa Fluor 488
NBP2-72942AF488
Alexa Fluor 532
NBP2-72942AF532
Alexa Fluor 594
NBP2-72942AF594
Alexa Fluor 647
NBP2-72942AF647
Alexa Fluor 700
NBP2-72942AF700
Alexa Fluor 750
NBP2-72942AF750
Allophycocyanin
NBP2-72942APC
Biotin
NBP2-72942B
CoraFluor 1
NBP2-72942CL1
DyLight 350
NBP2-72942UV
DyLight 405
NBP2-72942V
DyLight 488
NBP2-72942G
DyLight 550
NBP2-72942R
DyLight 594
NBP2-72942DL594
DyLight 650
NBP2-72942C
DyLight 680
NBP2-72942FR
DyLight 755
NBP2-72942IR
FITC
NBP2-72942F
HRP
NBP2-72942H
Janelia Fluor 525
NBP2-72942JF525
Janelia Fluor 549
NBP2-72942JF549
Janelia Fluor 585
NBP2-72942JF585
Janelia Fluor 635
NBP2-72942JF635
Janelia Fluor 646
NBP2-72942JF646
Janelia Fluor 669
NBP2-72942JF669
PE
NBP2-72942PE
PerCP
NBP2-72942PCP
View Available Formulations
Catalog# & Formulation Size Price
Azide and BSA Free
NBP2-72942
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NEU-1/Sialidase-1 Antibody (OTI3D4) Summary

Immunogen
Human recombinant protein fragment corresponding to amino acids 48-315 of human NEU1 (NP_000425)produced in E.coli.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
NEU1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:150
  • Immunohistochemistry-Paraffin
  • Western Blot 1:2000
Theoretical MW
40.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for NEU-1/Sialidase-1 Antibody (OTI3D4)

  • Acetylneuraminyl hydrolase
  • EC 3.2.1.18
  • exo-alpha-sialidase
  • FLJ93471
  • G9 sialidase
  • Lysosomal sialidase
  • N-acetyl-alpha-neuraminidase 1
  • NANH
  • NEU
  • NEU1
  • NEU-1
  • SIAL1
  • sialidase 1 (lysosomal sialidase)
  • Sialidase-1

Background

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon heterodimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses. Amplification and/or overexpression of Neu occurs in 20-30% of breast carcinomas. Measurement of increased Neu expression can be a predictor of disease prognosis. Neu may also prove to be a promising target for therapeutic agents.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NEU1