Natriuretic Peptide Receptor C Antibody (1060839) [Unconjugated] Summary
Immunogen |
Human embryonic kidney cell, HEK293-derived human NPRC/NPR3 Met1-Glu481 Accession # P17342 |
Specificity |
Detects human NPRC/NPR3 in direct ELISA. |
Source |
N/A |
Isotype |
IgG |
Clonality |
Monoclonal |
Host |
Mouse |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 5-15 ug/mL
|
Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Reconstitution Instructions |
Reconstitute at 0.5 mg/mL in sterile PBS. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Natriuretic Peptide Receptor C Antibody (1060839) [Unconjugated]
Background
Atrial Natriuretic
Peptide Receptor-3 (NPR3), also known as NPRC or ANPR-C, is one of the three natriuretic
peptide receptors (1, 2). Mature human NPR3 is a type I transmembrane
glycoprotein that contains a 455 amino acid (aa) extracellular domain (ECD), a
23 aa transmembrane segment, and a 37 aa cytoplasmic region. Within the ECD, human NPR3 shares 92% aa
sequence identity with mouse and rat NPR3. The natriuretic system is key to the maintenance of vascular tone and
cardiovascular homeostasis. It consists of three related natriuretic peptides:
atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type
natriuretic peptide (CNP). It also consists of three single-membrane-spanning
receptors (NPRs) to mediate the biological activity of these peptides: NPR1,
NPR2, and NPR3. NPR1 and NPR2 are guanylyl cyclase receptors that regulate cGMP
levels, while NPR3 lacks enzymatic activity and may act as a clearance receptor
(1, 2). Both ANP and BNP exhibit high binding affinities to NPR1 and NPR3,
while CNP binds with high affinity to NPR2 and NPR3 (2). NPR3 is known to be
expressed in the heart, lung, adrenal gland, heart, cerebral cortex, cerebellum,
liver and adipocytes and in some cancers (1, 2). Osteocrin was found to be a
specific ligand to NPR3 (3). NPR3 is necessary for Osteocrin to regulate
femoral, tibial, and metatarsal bone elongation (4).
- Potter, L.R. et al. (2006) Endocr. Rev. 27:47.
- Koller, K. J. and D. V. Goeddel (1992) Circulation 86:1081.
- Thomas, G. et al. (2003) J. Biol. Chem. 278:50563.
- Moffatt, P. et al. (2007) J. Biol. Chem. 282:36454.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for Natriuretic Peptide Receptor C Antibody (MAB10233) (0)
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