Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody

Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine. The mAChRs are present in neurons of the central and peripheral nervous systems, cardiac and smooth muscle and various exocrine glands. There are 5 subtypes (m1-m5) of the receptor that have a tissue specific pattern of expression. The m2 receptor is localized primarily in cardiac tissue and is also expressed at low levels in the hippocampus, cortex, striatum, thalamus, basal forebrain, brainstem, lung, vas deferens and uterus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-26152	Applications	Species
Iguchi N, Malykhina AP, Wilcox DT. Early life voiding dysfunction leads to lower urinary tract dysfunction through alteration of muscarinic and purinergic signaling in the bladder Am. J. Physiol. Renal Physiol. 2018-08-08 [PMID: 30089034] (WB, Mouse)	WB	Mouse
Hendershot CS, Bryan AD, Ewing SW et al. Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. J Abnorm Child Psychol 2011-07-01 [PMID: 21494862]

Array NBP2-26152

• Muscarinic Acetylcholine Receptor M2/CHRM2 Antibodies
• Muscarinic Acetylcholine Receptor M2/CHRM2 ELISA Kits
• Muscarinic Acetylcholine Receptor M2/CHRM2 Lysates
• Muscarinic Acetylcholine Receptor M2/CHRM2 Proteins