MTA2 Antibody

Gene Map Locus: 11q12-q13.1 (human) MTA2, a homologue of human MTA1 and MTA3, is a member of highly conserved MTA gene family. It is a component of NuRD, an ATP-dependent nucleosome remodeling and histone deacetylase complex. MTA2 is a nuclear protein that interacts with HDAC1 and HDAC2 and has a functional role in chromatin remodeling and deacetylase activity. MTA2 specifically interacts with p53 and represses p53-dependant transcriptional activation, thereby regulating p53-mediated cell growth arrest and apoptosis. It also inhibits the transcriptional activity of Estrogen receptor-alpha. Northern Blot analysis detected a ubiquitous expression of MTA2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-56483	Applications	Species
Quaas CE, Lin B, Long DT Transcription suppression is mediated by the HDAC1-Sin3 complex in Xenopus nucleoplasmic extract The Journal of biological chemistry 2022-10-08 [PMID: 36220390] (WB, Human)	WB	Human
An JX, Ma MH, Zhang CD et al. miR-1236-3p inhibits invasion and metastasis in gastric cancer by targeting MTA2 Cancer Cell Int. 2018-05-01 [PMID: 29743816] (WB, Human)	WB	Human
Errico A, Aze A, Costanzo V. Mta2 promotes Tipin-dependent maintenance of replication fork integrity. Cell Cycle 2014-05-15 [PMID: 24830473] (WB)	WB

Array NB100-56483

• MTA2 Antibodies
• MTA2 Proteins