Mouse TSLP Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. The activities of mouse TSLP overlap with, but are distinct from, those of mouse IL-7. Both mouse TSLP and IL-7 can co-stimulate growth of thymocytes and mature T cells, and support B lymphopoiesis in long-term cultures of fetal liver cells and bone-marrow cells. Whereas mouse IL-7 facilitates the development of B220⁺/IgM^- pre-B cells, mouse TSLP promotes the development B220⁺/IgM⁺ B cells. Human TSLP was reported to preferentially stimulate myeloid cells, inducing the release of T cell-attracting chemokines from monocytes and enhancing the maturation of CD11c⁺ dendritic cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence. Within the mature region, six of the seven cysteine residues present in the mouse TSLP involved in intramolecular disulfide bond formation are conserved in the human TSLP. Human TSLP shares approximately 43% aa sequence identity with mouse TSLP. By Northern blot analysis, human TSLP expression has been detected in many tissues with the highest expressions in heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex that consists of IL-7 R alpha and the TSLP R, a member of the hemopoietin receptor family most closely related to Rgamma_c.

TSLP R, also named Delta and CRLM-2 (Cytokine Receptor-like Module-2), was originally cloned as a novel type 1 cytokine receptor with similarity to the common gamma chain (gamma c). It was subsequently identified as a subunit of the cellular receptor for the IL-7-like cytokine TSLP and termed TSLP R. TSLP R shows 24% sequence identity with the mouse gc receptor. TSLP R expression is constitutive in immune and hematopoietic cells, but is up-regulated in Th2 cells.

We have publications tested in 2 confirmed species: Mouse, Transgenic Mouse.

Showing Publications 1 - 10 of 28. Show All 28 Publications. Collapse Publications.

Publications using MTLP00	Applications	Species
Harris, JC;Trigg, NA;Goshu, B;Yokoyama, Y;Dohnalová, L;White, EK;Harman, A;Murga-Garrido, SM;Ting-Chun Pan, J;Bhanap, P;Thaiss, CA;Grice, EA;Conine, CC;Kambayashi, T; The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally Cell reports 2024-04-03 [PMID: 38573852] (Mouse, Transgenic Mouse)		Mouse, Transgenic Mouse
Jin, J;Fan, YJ;Nguyen, TV;Yu, ZN;Song, CH;Lee, SY;Shin, HS;Chai, OH; Fallopia japonica Root Extract Ameliorates Ovalbumin-Induced Airway Inflammation in a CARAS Mouse Model by Modulating the IL-33/TSLP/NF-?B Signaling Pathway International journal of molecular sciences 2023-08-07 [PMID: 37569890] (Mouse)		Mouse
H Tallima, R El Ridi Increased hepatic interleukin-1, arachidonic acid, and reactive oxygen species mediate the protective potential of peptides shared by gut cysteine peptidases against Schistosoma mansoni infection in mice PloS Neglected Tropical Diseases, 2023-03-15;17(3):e0011164. 2023-03-15 [PMID: 36920999] (Mouse)		Mouse
RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Mouse)		Mouse
Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease EBioMedicine, 2022-09-28;85(0):104285. 2022-09-28 [PMID: 36182776] (Mouse)		Mouse
W Chang, H Lv, L Tan, Z Gao, P Liu, D Qin, W Zhang, Y Xu Downregulation of deubiquitinating enzyme USP25 promotes the development of allergic rhinitis by enhancing TSLP signaling in the nasal epithelium Molecular Medicine Reports, 2022-09-30;26(5):. 2022-09-30 [PMID: 36177892] (Mouse, Transgenic Mouse)		Mouse, Transgenic Mouse
S Shibata, A Kuwahara, M Sakaki-Yum, M Kawaguchi, T Ishii, Y Honma Effects of the dipeptide L-glutamic acid-L-tryptophan on dermatitis in mice and human keratinocytes Heliyon, 2022-01-07;8(1):e08729. 2022-01-07 [PMID: 35036609] (Mouse)		Mouse
Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li, Q Xia, Q Zhao, L Huang, S Jiang, S Su Eosinophil extracellular traps drive asthma progression through neuro-immune signals Nature Cell Biology, 2021-10-06;23(10):1060-1072. 2021-10-06 [PMID: 34616019] (Mouse)		Mouse
KJ Warren, JA Poole, JM Sweeter, JM DeVasure, JD Dickinson, RS Peebles, TA Wyatt Neutralization of IL-33 modifies the type 2 and type 3 inflammatory signature of viral induced asthma exacerbation Respiratory Research, 2021-07-15;22(1):206. 2021-07-15 [PMID: 34266437] (Mouse)		Mouse
W Zhou, J Zhang, S Toki, K Goleniewsk, AE Norlander, DC Newcomb, P Wu, KL Boyd, H Kita, RS Peebles COX Inhibition Increases Alternaria-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice J. Immunol., 2020-07-20;0(0):. 2020-07-20 [PMID: 32690653] (Mouse)		Mouse
S Li, Z Yi, M Deng, MJ Scott, C Yang, W Li, Z Lei, NM Santerre, P Loughran, TR Billiar TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway JCI Insight, 2019-11-14;4(22):. 2019-11-14 [PMID: 31723054] (Mouse)		Mouse
N Gago-Lopez, LF Mellor, D Megías, G Martín-Ser, A Izeta, F Jimenez, EF Wagner Role of bulge epidermal stem cells and TSLP signaling in psoriasis EMBO Mol Med, 2019-09-26;0(0):e10697. 2019-09-26 [PMID: 31556482] (Mouse)		Mouse
X Cui, N Gao, R Me, J Xu, FX Yu TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway Invest. Ophthalmol. Vis. Sci., 2018-08-01;59(10):4228-4237. 2018-08-01 [PMID: 30128494] (Mouse)		Mouse
MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Mouse)		Mouse
KP Ganti, A Mukherji, M Surjit, M Li, P Chambon Similarities and differences in the transcriptional control of expression of the mouse TSLP gene in skin epidermis and intestinal epithelium Proc. Natl. Acad. Sci. U.S.A, 2017-01-23;0(0):. 2017-01-23 [PMID: 28115699] (Mouse)		Mouse
Hoste E, Arwert E, Lal R, South A, Salas-Alanis J, Murrell D, Donati G, Watt F Innate sensing of microbial products promotes wound-induced skin cancer. Nat Commun, 2015-01-09;6(0):5932. 2015-01-09 [PMID: 25575023] (Mouse)		Mouse
Cipolat S, Hoste E, Natsuga K, Quist S, Watt F Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility. Elife, 2014-05-05;3(0):e01888. 2014-05-05 [PMID: 24843010] (Mouse)		Mouse
Hara K, Iijima K, Elias M, Seno S, Tojima I, Kobayashi T, Kephart G, Kurabayashi M, Kita H Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol, 2014-03-24;192(9):4032-42. 2014-03-24 [PMID: 24663677] (Mouse)		Mouse
Mlacki , Michal, Darido , Charbel, Jane , Stephen, Wilanowski , Tomasz Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin. PLoS ONE, 2014-02-20;9(2):e89247. 2014-02-20 [PMID: 24586629] (Mouse)		Mouse
Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol., 2011-12-23;188(3):1503-13. 2011-12-23 [PMID: 22198948] (Mouse)		Mouse
Taube C, Tertilt C, Gyulveszi G, Dehzad N, Kreymborg K, Schneeweiss K, Michel E, Reuter S, Renauld JC, Arnold-Schild D, Schild H, Buhl R, Becher B IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease. PLoS ONE, 2011-07-18;6(7):e21799. 2011-07-18 [PMID: 21789181] (Mouse)		Mouse
Kashyap M, Rochman Y, Spolski R Thymic stromal lymphopoietin is produced by dendritic cells. J. Immunol., 2011-06-20;187(3):1207-11. 2011-06-20 [PMID: 21690322] (Mouse)		Mouse
Tsai M, Chen CC, Mukai K Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice. Am. J. Pathol., 2010-09-09;177(5):2411-20. 2010-09-09 [PMID: 20829437] (Mouse)		Mouse
Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K, Nakao A Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur. J. Immunol., 2009-11-01;39(11):3078-83. 2009-11-01 [PMID: 19658093] (Mouse)		Mouse
Demehri S, Turkoz A, Kopan R Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell, 2009-07-07;16(1):55-66. 2009-07-07 [PMID: 19573812] (Mouse)		Mouse
Demehri S, Morimoto M, Holtzman MJ Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol., 2009-05-19;7(5):e1000067. 2009-05-19 [PMID: 19557146] (Mouse)		Mouse
Boehme SA, Franz-Bacon K, Chen EP, Sasik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. Int. Immunol., 2008-12-09;21(1):81-93. 2008-12-09 [PMID: 19066314] (Mouse)		Mouse
Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum., 2008-11-01;58(11):3510-9. 2008-11-01 [PMID: 18975342] (Mouse)		Mouse
Show All 28 Publications. Collapse Publications.

Array MTLP00

• TSLP Antibodies
• TSLP Kit
• TSLP Lysates
• TSLP Proteins
• TSLP Proteins and Enzymes
• TSLP ELISAs